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- A mad scientist kidnaps and mutilates a trio of tourists in order to reassemble them into a human centipede, created by stitching their mouths to each others' rectums.
- Three women who have been driven mad by pioneer life are to be transported across the country by covered wagon by the pious, independent-minded Mary Bee Cuddy, who in turn employs low-life drifter George Briggs to assist her.
- Two lighthouse keepers try to maintain their sanity while living on a remote and mysterious New England island in the 1890s.
- In the dying days of the old west, an elderly sheriff and his posse set out to rescue their town's doctor from cannibalistic cave dwellers.
- Four college girls hold up a restaurant in order to fund their spring break vacation. While partying, drinking, and taking drugs, they are arrested, only to be bailed out by a drug and arms dealer.
- A single mother and her child fall into a deep well of paranoia when an eerie children's book titled "Mister Babadook" manifests in their home.
- A punk rock band is forced to fight for survival after witnessing a murder at a neo-Nazi skinhead bar.
- Inspired by the fictional Dr. Heiter, disturbed loner Martin dreams of creating a 12-person centipede and sets out to realize his sick fantasy.
- Wrongfully convicted for murder, Henri Charriere forms an unlikely relationship with fellow inmate and quirky convicted counterfeiter, Louis Dega, in an attempt to escape from the notorious penal colony on Devil's Island.
- Follows Stevie, a thirteen-year-old in 1990s-era Los Angeles who spends his summer navigating between his troubled home life and a group of new friends that he meets at a Motor Avenue skate shop.
- In small-town Texas, an affable mortician strikes up a friendship with a wealthy widow, though when she starts to become controlling, he goes to great lengths to separate himself from her grasp.
- A father and his daughter struggle to survive in deep space where they live in isolation.
- A pair of childhood friends and neighbors fall for each other's sons.
- A former American intelligence specialist was given the longest sentence for the unauthorized release of government information to the media about Russian interference in the 2016 United States elections via an email operation.
- Taking inspiration from The Human Centipede films, the warden of a notorious and troubled prison looks to create a 500-person human centipede as a solution to his problems.
- A prestigious Stockholm museum's chief art curator finds himself in times of both professional and personal crisis as he attempts to set up a controversial new exhibit.
- A seventeen-year-old navigates his survival amongst an explosive criminal family and the detective who thinks he can save him.
- On the margins of Tokyo, a dysfunctional band of outsiders are united by loyalty, a penchant for petty theft and playful grifting. When the young son is arrested, secrets are exposed that upend their tenuous, below-the-radar existence.
- Jep Gambardella has seduced his way through the lavish nightlife of Rome for decades, but after his 65th birthday and a shock from the past, Jep looks past the nightclubs and parties to find a timeless landscape of absurd, exquisite beauty.
- An introverted teenage girl tries to survive the last week of her disastrous eighth grade year before leaving to start high school.
- When contaminated meat is placed in the freezer next to that used for a fast food chain's most famous sandwich, a marketing executive seeks to find out who did it and why, taking a journey through the dark side of American alimentation.
- A mysterious outsider's quiet life is turned upside down when he returns to his childhood home to carry out an act of vengeance. Proving himself an amateur assassin, he winds up in a brutal fight to protect his estranged family.
- A minister of a small congregation in upstate New York grapples with mounting despair brought on by tragedy, worldly concerns and a tormented past.
- When 30-something Jesse returns to his alma mater for a professor's retirement party, he falls for Zibby, a college student, and is faced with a powerful attraction that springs up between them.
- In 1997 Rio de Janeiro, Captain Nascimento has to find a substitute for his position while trying to take down drug dealers and criminals before the Pope visits.