- On September 1, 2005, when Hurricane Katrina was approaching New Orleans, he decided to remain at his home and was missed for days. He was later rescued by a Coast Guard helicopter.
- Although never really in the mainstream of early rock and roll, he was one of the most influential singers in rock. He was one of the biggest stars of rock and roll in the 1950s and one of the first rhythm and blues artists to gain popularity with white audiences.
- He was awarded a Star on the Hollywood Walk of Fame for Recording at 6616 Hollywood Boulevard in Hollywood, California on February 8, 1960.
- He was voted the 25th Greatest Rock 'n' Roll Artist of all time by Rolling Stone.
- In 1957, his brother-in-law approached him with a song he had written that he thought would be perfect for Fats. However, Domino turned down the song. The song was "You Talk Too Much" and was later recorded by Joe Jones, reaching #3 on the Billboard charts.
- He was awarded the American National Medal of the Arts by the National Endowment of the Arts in Washington, D.C. (1998).
- He was awarded a star on the Delta Music Museum Walk of Fame in Ferriday, Louisiana.
- Had numerous hit songs between 1952 and 1960, including "Ain't That a Shame", "When My Dreamboat Comes Home", "Blueberry Hill", "I'm Walkin'", "Valley of Tears", "It's You I Love", "Whole Lotta Love", "I Want to Walk You Home" and "Be My Guest".
- Mentioned in the song "Life Is a Rock But the Radio Rolled Me" by Reunion.
- Following his death, he was interred at Providence Memorial Park and Mausoleum in Metairie, Jefferson Parish, Louisiana. He passed away on October 24, 2017, four months away from what would have been his 90th birthday on February 26, 2018.
- Inducted into the Rock and Roll Hall of Fame (1986), the American Songwriters Hall of Fame (1998), the Louisiana Music Hall of Fame (2007), and the Rhythm and Blues Music Hall of Fame (2016).
- First worked as an iceman and in a bedspring factory before landing a gig at a New Orleans nightclub which led to his first recording contract with Imperial Records.
- He survived a near deadly automobile accident early in his career and nearly lost a hand in a factory accident.
- He resided in a mansion in a predominantly working-class neighborhood in the Lower Ninth Yard, where he was a familiar sight in his pink Cadillac automobile.
- Had eight children, most of them whose names begin with the letter 'A': Antoine Domino III, Anatole Domino, Andre Domino, Antonio Domino, Antoinette Domino, Andrea Domino, Anola Domino and Adonica Domino.
- He did not get his famous moniker as a result of his first hit, "The Fat Man" (1949) (which sold more than a million copies). In fact, that event took place when he was ten years old playing honky-tonk piano at the Hideaway Bar, where the resident bandleader Bill Diamond gave him the nickname.
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