• I think, as I've gotten older I have realized what a huge privilege it is to even be in this business. I, more than ever, love what I do.
  • I'm just looking always for characters that change, because I want to get better, as an actor and as a person.
  • [from his 1997 "Playgirl" magazine interview, on whether he wants to get married someday] Yes, I do. But I don't have any immediate plans because I know I wasn't good at it the first time around.
  • [in his "TV Tattler" interview, regarding the relationship with his television sons Jared Padalecki and Jensen Ackles] On set, we're like three idiot brothers.
  • [about coming back to Supernatural (2005)] "I'm going to call Eric [series creator Eric Kripke] and beg for my life and find a way to come back and harass these guys [Jensen Ackles and Jared Padalecki] in some way.
  • I love Jared and Jensen. Going up to Vancouver is like going to camp. We have so much fun, and it's pretty much just the three of us up there. There's a lot of giggling. The three of us together act like little kids. They're both fun as heck, but they're both so different. Supernatural is the most difficult because I could never get used to working nights. Working exterior nights in Vancouver, when it's raining and snowing, is a little daunting, when you haven't slept. The show is extremely hard, physically. - on working with Jared Padalecki and Jensen Ackles on Supernatural (2005).
  • [Told Flaunt Magazine in March 2010 that he currently abides by these steadfast rules] We don't tattoo someone's name on our body and we don't get married.