- A former Screen Actors Guild board member, she later went on to become president of the Academy of Television Arts and Sciences.
- The scene where her L.A. Law (1986) character Rosalind Shays is discovered in bed with her enemy Leland McKenzie, played by Richard Dysart, was ranked as the 38th greatest moment in television (the list originally appeared in the March 1991 issue of EGG magazine).
- Said in an interview in People Magazine in 2000, that the L.A. Law (1986) actors were like family to her, but that she didn't have fond memories of the cast of Star Trek: The Next Generation (1987).
- In celebration of the Star Trek (1966) 40th Aniversary, several conventions were held in its honor. Diana hadn't done a Star Trek convention in 10 years. She participated in one in Las Vegas on Sept. 15, 2006, along with several other Star Trek veterans.
- According to director Paul Lynch, Diana had trouble remembering her lines on Star Trek: The Next Generation (1987). To help her out, her lines were put on cue cards for her to look at. (Star Trek magazine, Sept/Oct 2007).
- Appeared in the TV episode Fandango (1967), a portion of which can be heard on the album "The Wall" by Pink Floyd, during the intro to the song "Is There Anybody Out There".
- Often plays characters with the title Doctor. Her most noted ones in Trek lore were, respectively: biologist "Dr. Ann Mullhall" (original series episode: Return to Tomorrow (1968)), psychologist "Dr. Miranda Jones" (original series episode: Is There in Truth No Beauty? (1968)) and physician "Dr. Katherine Pulaski" (season two of Star Trek: The Next Generation (1987)). Each having an open-minded view of the Universe.
- Fairly well-known breeder, owner, and judge of Airedale Terriers.
- Martha's Vineyard, MA, USA: Looking for a suitable role to restart her career, after being a caregiver to her husband for many years. (January 2013)
- Playmates Toys released an action figure in her likeness as the character "Dr. Pulaski" from Star Trek: The Next Generation (1987).
- 1960 graduate of Sweet Briar College. Was the school's commencement speaker forty years later, on May 7, 2000.
- Ex-sister-in-law of musician Maria Muldaur.
- Diana's younger brother is singer/songwriter Geoff Muldaur.
- Worked together with L.A. Law (1986) co-star Richard Dysart at New York's legendary "Circle in the Square Theatre" in the 1960s.
- Her cousin was the father of actress Kathy Baker.
- Had played scientists on the original Star Trek series before being called in to play Dr. Pulaski on Star Trek: The Next Generation (1987). She agreed to take the role on one condition: that the character's first name be changed to Catherine. Gates McFadden, during her time off, played another doctor, Caroline Ryan, in The Hunt for Red October (1990). When McFadden returned to Star Trek, she was unable to appear in Patriot Games (1992), and her role was given to Anne Archer, and renamed Catherine.
- Aunt of Jenni Muldaur and Clare Manchon.
- Did not find her tenure on Star Trek TNG a happy experience, leaving after just one season. According to Gene Roddenberry, the decision "to let her go was made solely because the hoped-for chemistry between her and the rest of the starship cast did not develop.".
- Studied acting under Stella Adler.
- Graduating from Sweet Briar College in Virginia in 1960.
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