- Her mother was only fifteen years old when Misti was born.
- Misti was a competitive figure skater.
- Her parents are actress Kiersten Warren and (stepfather) screenwriter Jonathan Lemkin.
- Stepdaughter of Kirk Acevedo.
- She speaks French.
- Gave birth to her 1st child at age 30, a daughter named Helena Primrose Jeffreys on December 6, 2011. Child's father is her husband, Henry Jeffreys.
- She has two dogs: a Maltese named Bailey Jane and an orange sable Pomeranian named Snacks.
- She is the grand-daughter of once-upon-a-time Southern Baptist missionaries.
- Once for school credit, Misti and one of her friends started an online literary magazine called "The Pretentious Dilettante." It was composed mostly of satirical essays that exploit friction between high and low culture, ranging in issues from the pretentions of the former to the deficiency of the latter and much else in between. "Pretentious Dilettante" delved in comical fashion into the inanity of celebrity and played with the idea of how its cult infiltrates even the most serious minded.
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