- Was the long time writing partner and opening act for comedian Greg Giraldo.
- Briefly worked in advertising right out of college. Won 2 American Advertising Awards "Addys" for writing and graphic design.
- Began doing stand up at the age of 18 while attending Duquesne University in Pittsburgh.
- His uncle Mike Joyce was briefly a stand up comedian and a clown with Ringling Brothers and Barnum & Bailey Circus.
- Wrote numbers 2 and 7 on Comedy Central's list of The Top 10 Best Roast Jokes of All Time. 7: "Ice-T is so old the first thing he bought with his record deal money was his freedom" 2: "Lisa Lampanelli is a lot like the OctoMom. She hasn't had 8 babies, but she has had 80 fingers inside her at the same time.".
- Additionally Jesse often writes for Seth MacFarlane, Jim Norton, Dave Attell, Jeff Ross, Robert Smigel, (the late) Greg Giraldo,and on rare occasion Matt Lauer.
- Studied art at Carnegie Mellon University and Duquesne University. His work has been displayed at The Pittsburgh International Airport, and he designed a plaque to Roberto Clemente that hangs in PNC Park. He also designed the logo for Ameriserv Financial Bank.
- As of 5-7-15, Jesse Joyce is currently ranked #9th on the @midnight with Chris Hardwick Leader Board with 4 wins in 6 appearances and a total score of 20,700 points.
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