Poll: AAACK? Cathy on the big screen?

Cathy was the title character in the United States nationally syndicated comic strip from 1976 to 2010 called Cathy by Cathy Guisewite. Through most of the life of the series, our femme forsaken was searching for Mr. Right via the neurotic hunting grounds of the dating scene. Which of these lovable losers (comic actresses and comedians) would you cast as lead in a hypothetical cinematic adaptation of the comic strip? Bring your pick from casting couch to a therapist's couch here.