Over thirty actors auditioned for the lead role, with William Shatner the eventual winner, though he then declined it. James Franciscus was also offered the role, but had committed himself to another (eventually unmade) series at the time.

The large white building shown at the beginning of each episode that was "Blair General Hospital" was actually the Irving Thalberg Building on the MGM Pictures lot.

The establishing shots of Blair General Hospital in the series are from the first Dr. Kildare movie, Young Dr. Kildare (1938).