- Moderate
- Hank's friend Dale smokes frequently throughout the series.
- The season 1 episode "Keeping Up With Our Joneses" addresses the issue of cigarette smoking, with Bobby smoking cigarettes, as well as Hank and Peggy, including in flashbacks.
- Bobby and Tid-Pao team up for the school science fair; unbeknownst to Bobby, Tid-Pao gets him to steal supplies to help her build a meth lab, which is later taken by bobby to the school.
- Peggy drugs Hank with testosterone pills. A testosterone drug product called the Scrota-Bond (a wear-on patch) is also featured.
- Kahn is manic-depressive and uses prescription drugs. After failing to refill the prescription, Hank buys illegal pills in Mexico for him.
- Hank's friends drinks beer at the intro through out the whole series.
- Almost all episodes show beer and cigarettes, but most children have seen smoking and drinking in real life.
- Children might not pay much attention to the references to drugs such as weed or meth.
- Even though this is a family show, some parents might want children to be supervised while viewing.
- Contains frequent depictions of casual smoking and drinking.
- Some episodes contain references to illegal drugs and drug smuggling.
- In one episode, a character inadvertently smokes marijuana, much to his horror. Illegal drug use is neither condoned nor glamorized throughout the series.