The neurological condition that Lucy suffers from, Goldfield Syndrome, is entirely fictional. True anterograde amnesia affects either short-term memory, which can last minutes or seconds, or intermediate-term memory, which can last days or weeks. Falling asleep has nothing to do with the condition, and sleep actually intensifies many chemical effects which help memory.
In an early scene a dentist and a woman in the dentist's chair are seen talking with each other. The woman playing the dentist is Jackie Sandler, Adam Sandler's wife. And the woman in the chair is played by Linda Segal, director Peter Segal's wife, who actually is a dentist in real life.
The book Lucy reads at breakfast, "Still Life With Woodpecker - A Sort Of A Love Story" by Tom Robbins, is a love story set in Hawaii.
The clinic that Lucy visits is called the "Callahan Institute" and Dr. Keats (Dan Aykroyd) states that it is "funded out of Sandusky, Ohio by T.B. Callahan, the automotive components tycoon". In Tommy Boy (1995), Aykroyd plays a rival automotive components tycoon that is attempting to purchase Tom (T.B.) Callahan's company.
The diner where Lucy has her breakfast every morning was originally a house that was remodeled for the movie. It is located on a macadamia nut farm on the eastern side of Oahu. The same house was used in Tears of the Sun (2003) and scenes from Jurassic Park (1993) were filmed in the open fields nearby.
Henry makes a video for Lucy to remind her of the events that have occurred since her accident. One of the items is "Red Sox win the World Series..." followed by "... Just Kidding". During the year of the film's release, the Red Sox actually broke an 86-year drought and won the World Series. Drew Barrymore made the movie Fever Pitch (2005) about an avid Red Sox fan and they filmed the final scene on the Busch Stadium field while the Red Sox celebrated winning the 2004 World Series.
Maya Rudolph makes an appearance in this movie as Lucy's pregnant friend. She would later go on to star in Grown Ups alongside Adam Sandler and Rob Schneider but plays Chris Rock's pregnant wife.
The original script set the movie in Seattle, the hometown of scriptwriter George Wing.
"Jocko" was played by Sivuqaq, one of four walruses living at Six Flags Marine World in Vallejo, CA. The three female walruses featured in the film are named Siku, Uquq and Qiluk.
There are several references to the Hormel meat product Spam in the movie. According to Hormel, Hawaii leads the nation in per capita consumption of Spam. Over 6.7 million cans are sold annually in Hawaii, which equals 5.5 cans per year per Hawaiian.
Inspiration for this film was taken from Harold Ramis' romantic comedy "Groundhog Day" (1993).
Blake Clark, Who is a Vietnam Veteran with the US Army, wears a hat from the USS Badger (DE 1071)named after Admiral Oscar C. Badger II, Charles J. Badger's son, (1890-1958) was the first Navy officer to step ashore in Japan at the end of World War II and was also awarded the Naval Medal of Honor.
Both Henry and Doug had relationship issues with a girl named "Tracy", Henry during college and Doug in high school.
Actor/Producer Anthony Begonia was set to play a cameo as an ukulele player but was unavailable.
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