- Moderate
- 2 brothers are implied to have an incestuous relationship, though we actually never see this happening. These brothers however only appear about once or twice a season.
- Almost all episodes have no sex or nudity at all (other than dialogue), but some episodes have brief sex scenes (nothing graphic).
- Season 11 features a non graphic implied scene.
- In the episode The Gang Hits the Slopes. A woman goes into a hot tub topless as Charlie watches her. Charlie is uncomfortable and nervous in the situation but the woman asks if he does not like her breasts. The woman invites Charlie into the hot tub and they start kissing and Charlie takes his clothes off. In the next shot, Charlie and the woman are shown having sex in a hotel room. Although the woman's breasts are blurred out the entire time.
- In the episode The Gang Goes to the Jersey Shore. Charlie, Dennis and Dee walk under a boardwalk and they walk by a couple of homeless men having anal sex and they're shocked. There's brief nudity of the men's buttocks.
- In the episode The D.E.N.N.I.S. System. Dennis and his girlfriend have sex but the scene is brief and dark. They tongue kiss too.
- In season 2, episode 1, the guys go to a strip club and multiple strippers are seen wearing very skimpy clothing. Strippers are dancing on tables, lots of cleavage and buttcheeks are shown. They also take two back to their room and the strippers are in their bra and underwear having a pillow fight.
- In the episode Charlie and Dee Find Love. There is a recorded video of Mac and Trevor in Dennis' room. They're both shirtless and oily. It shows them having sex for a few seconds and the video stops.
- Prostitution is a recurring subject matter, but it is usually played for dark comedy. As such, prostitutes are never hired.
- There are two sex scenes, with only one that contains nudity as well many positions, lasting around a minute, but both of these occur in the much later seasons.
- It is implied that Charlie and Dee had sex.
- It is implied that Charlie was sexually abused as a child by his uncle. His musical "The Nightman Cometh" has multiple references to this and it's a very sad topic.