The crew was allowed to film inside the Roman Colosseum for three days, under three conditions: no equipment could be placed on the ground, they could only shoot from 6:30 a.m. to 8:30 a.m. and from 3:30 p.m. to 5:30 p.m. to avoid disturbing tourists, and the only lighting allowed was natural sunlight.
Many parts of the film are different from the book. Some of them include the characters of Roland, Griffin, and the Paladins. In the book, the main character goes by Davy, not David. Davy was the only Jumper in the book; however, Griffin's character changes this. In the movie, David knew Millie from school. In the book, they met after he ran away to New York City. In the book, David and Millie do not travel to Rome. The book spends a lot of time with Davy trying to find his mother and being tracked and investigated by the NSA, which has been replaced with the Paladin story arc.
Hayden Christensen (David) and Rachel Bilson (Millie) met on the set and became engaged, but split up in September 2017.
Eminem reportedly turned down an offer to star in the lead role. However, an MTV report quoted director Doug Liman saying his plan to have Eminem in the movie was dropped right after he met Hayden Christensen.