During the first episode "The Key", Miller leaves his daughter with a child psychologist in a clinic. When he is leaving, you can hear a call for a "Doctor Sonny Gupta" via the speaker system of the clinic. "Doctor Sonny Gupta" is a character in Kingdom Hospital (2004) (2004), written by Stephen King and directed by Craig R. Baxley.

In "The Eye and the Prime Object," the cartoon Isaac is watching in the beginning is To Build a Better Mousetrap (1999), an animated short by series co-creator Christopher Leone.

In the Lost Room Promo that aired on the SciFi Channel, it has a different child actress being lost in the room than was actually used in the mini-series.

The name "Dr. Sonny Gupta" is also a pun on the name of Dr. Sanjay Gupta, a frequent on-air medical contributor of CNN.