After Megamind has taken over the town, his large "No you can't" posters are a reference to President Barack Obama's 2008 campaign posters featuring the slogan "Yes we can".
Ben Stiller and Robert Downey, Jr. were approached for the role of Megamind, but turned it down due to scheduling conflicts. Stiller, however, appears in the role as Bernard the curator.
To promote the film, Will Ferrell assembled 1,580 of his friends and their acquaintances at a superhero costume function. This party set a Guinness World Record for the largest gathering of superheroes.
There are numerous references to Superman in this film: The way Megamind's parents put him in a capsule to Earth just before his planet is destroyed. The love interest is a reporter. Hal's "space dad" is modelled after Marlon Brando, as Superman (1978)'s father in Richard Donner's film version. Almost all of Metro Man's super powers are the same as Superman's. Megamind's pronunciation of Metro City has the same stress pattern as 'Metropolis" in Superman. Megamind takes on a bespectacled secret identity similar to Clark Kent. In the Metro Man Museum, there's a statue of Metro Man preparing to catch an airplane. This is a reference to John Byrne's Superman comics, where Superman made his first appearance by catching a plane and saving Lois Lane.
Megamind mispronounces words twenty times throughout the movie, most noticeably Metro City as "Metrocity" (rhyming with atrocity).
Megamind's dehydration gun also bears the commands DECOMPRESS, DEBILITATE, DEMORALIZE, DECOUPAGE, DEREGULATE, DEATH RAY, and DESTROY.
Metro City is located in Michigan. This can be clearly seen in a shot where Megamind's satellite is in orbit around the Earth.
Megamind's invisible car is a combination of two famous superhero vehicles: the Batmobile and Wonder Woman's invisible plane.
Guillermo del Toro was hired as a creative consultant three weeks before the film completed production. He majorly assisted in editing the film to make it more exciting.
The film was originally titled "Master Mind". However, the name had already been trademarked by the makers of the 1970s board game and television show Mastermind (1972), so it could not be used. It was then going to be titled "Oobermind", which was a misspelling of the term "über-mind." The word "über" refers to something that is large or great; in this case, the title character's over-swollen skull/brain. But it didn't sound right, so it was revised to become "Megamind".
Hal Stewart is named after two characters who have held the title of the Green Lantern, Hal Jordan and John Stewart.
Massachusetts Branch Showcase Cinema accidentally showed Saw 3D: The Final Chapter (2010) instead of Megamind at the time of Megamind 's release, frightening young audiences.
David Cross was based in London during production, so his performance was literally phoned in.
Brad Pitt's first voice acting job since Sinbad: Legend of the Seven Seas (2003), another DreamWorks film.
Each of the three superhumans in the film has a unique color scheme: Megamind's prominent color is blue, Metro Man is always seen with white, and Titan is colored red.
Instead of voicing his character from within a sound booth, Brad Pitt, who is a very active actor, insisted on using a handheld microphone for his performance and roaming around the studio.
When Megamind (Will Ferrell) is channel surfing towards the end of the movie, he comes upon a news report of a squirrel water skiing. Ferrell had played Ron Burgundy in Anchorman: The Legend of Ron Burgundy (2004), in which Burgundy does a report on a water skiing squirrel.
Despite a worldwide gross in excess of three hundred twenty million dollars, this is one of DreamWorks Animation's lowest grossing films.
Some of the words on Hal's t-shirts include "Game Over" and "Error 404: Request Not Found".
In the last dance scene during "Bad", Megamind does the Dougie, the Stanky Leg, and the Jerk.
According to Director Tom McGrath, the film drew inspiration from Batman: The Movie (1966) and Superman (1978).
This movie was promoted at the 2010 San Diego Comic-Con International, with Tom McGrath, Tina Fey, Jonah Hill, and Will Ferrell, who was dressed as Megamind.
Megamind plays a snippet of Minnie Ripperton's "Loving You" after supposedly killing Metro Man and taking over Metro City. Will Ferrell, the voice of Megamind, was castmates on Saturday Night Live (1975) with Ripperton's daughter, Maya Rudolph.
The film's Japanese release was cancelled, following the devastating 2011 earthquake and tsunami.
When Megamind trains Hal, he uses a training regiment based on Hal's love of video games. This is similar to Kung Fu Panda (2008), where Po was trained through food-based exercises.
The idea that Megamind chose the name "Titan" for Hal's alter ego, because it was the only name he could trademark is amusing, but not factual. There have been several superheroes named "Titan". Most notably, by Dark Horse comics beginning in 1993.
The second collaboration between Will Ferrell and David Cross. The first was Curious George (2006), which was also animated.
Second DreamWorks Animation film where "Little Less Conversation" by Elvis Presley is played at some point in the film, after Shark Tale (2004).
Third DreamWorks Animation film for Ben Stiller, after Madagascar (2005) and Madagascar: Escape 2 Africa (2008), which also had been directed by Tom McGrath.
One of the venues, on which Megamind trains Hal to be Titan, is the same venue used in Donkey Kong, complete with rolling barrels and angled surfaces.