Sofia Lamb (voice)
Augustus Sinclair (voice)
Brigid Tenenbaum (voice)
Eleanor Lamb (voice)
Young Eleanor Lamb (voice)
Andrew Ryan (voice)
Grace Holloway (voice)
Father Simon Wales (voice)
Daniel Wales / Warden Nigel Weir (voice)
Stanley Poole (voice)
Gil 'Alex the Great' Alexander (voice)
Babyjane (voice)
Breadwinner (voice) (as Adam Seitz)
Brute (voice) (as Rick Wasserman)
Crawler (voice)
Ducky / Toasty (voice)
Dr. Grossman (voice)
Ladysmith (voice)
Little Sister (voice)
Oscar (voice)
Buck (voice)
Naledi (voice)
Mlle Blanche (voice)
Zigo (voice)
Danny (voice)
Jacob (voice)
Barbara (voice)
Suresh / Sinclair Solutions Spokesman (voice)
Louie (voice)
Mark Meltzer (voice)
Atlas / Fontaine (voice)
Additional Voices (voice)
Big Kate O'Malley / Lizzy Fletcher / Persephone System PA (voice) (as D.B. Cooper)
Atlantic Express Gossiping Baby Jane Splicer (voice)
Jean-Paul Beauregard (voice)
Thomas / Dr. Grimes's Patient (voice)
Mike Novak / Gideon Wyborn / Tommy Hanrahan (voice) (as Ray Guth)
Additional Voices (voice) (as Laney Andreychuk)
Thomas / Additional Voices (voice)
Prentice Mill / Rock Flanagan (voice)
Ava Tate (voice)
Public Service Announcements / Security Announcer (voice) (as Elizabeth Foldes-Meiman)
Charles Milton Porter (voice)
Pearl Porter (voice)
Reed Wahl (voice)
Buttons (voice)
Heady (voice) (as Prudence Holmes)
Additional Voices - Minerva's Den (voice)
Evelyn Klein - Minerva's Den (voice)
Additional Voices - Minerva's Den (voice) (as John Bentley)
Splicer (voice)
Big Daddy (voice)
Various Voices (voice)
Additional Voices (voice) (uncredited)