When Larry is getting fired for not going to college, Jack Strang (Rob Riggle's character) holds up his class ring and says "SMU Class of 1986. Solid gold. They weren't giving these things away." In 1986, SMU was given "The Death Penalty" by the NCAA for major infractions, including graduating students who had not earned an academic degree.

This movie is based on the life of a friend of Tom Hanks called Jim Chandler.

After being given the news that he was going to be cast as the husband of Julia Roberts' character, Bryan Cranston went on an accelerated workout and diet regiment. He also bleached his teeth white. Cranston claimed it was an attempt to come as close as possible to convince people that his character would be married to someone like Roberts, by having a younger looking character.

According to Universal Pictures, almost 75 percent of the movie's audience, on opening weekend, was older than 50.

Tom Hanks performed a few tasks on this movie. He was the lead actor, co-writer, producer, and director.

The last name of the lady at the bank is Gamelguard. This is a reference to That Thing You Do! (1996) (also with Tom Hanks). It is the same last name as the boy who last 'decently' kissed Faye (Liv Tyler). This is one of the last lines of the movie.

Chet Hanks, the son of Rita Wilson and Tom Hanks, appears in a bit part as a pizza delivery boy. Rita also has a supporting role.

Nia Vardalos co-wrote this film with Tom Hanks. Hanks has worked with Vardalos before, as a producer, on her films My Big Fat Greek Wedding (2002), Connie and Carla (2004), My Life in Ruins (2009), and My Big Fat Greek Wedding 2 (2016). This movie is the first time that they have collaborated on a screenplay.

Second film directed by Tom Hanks. His first was That Thing You Do! (1996).

The fictional "U-Mart" where Larry works is actually a K-Mart. Based on the color scheme and the outtakes on the DVD where Tom Hanks mentions about being able to "find everything they need at K-Mart".

Second top-billed star-teamed movie of Tom Hanks and Julia Roberts. Their first was Charlie Wilson's War (2007).

Filmed at various locations on the Cal State Dominguez Hills campus in Carson, California.

There are many references to the fact that Larry's last name is Crowne (crown logos, etc.), including his alias, Lance Corona, as Corona in Spanish means 'crown'.

Julia Roberts had just begun shooting Eat Pray Love (2010) in Rome, when she was first offered the script for this movie.

When the scooter "gang" rides into Larry's neighborhood for the yard sale, Lamar (Cedric the Entertainer's character) yells "We're being invaded!", which is a line from That Thing You Do! (1996). The line is first given by the character "Goofball" on the fictional set of "Weekend at Party Pier". Tom Hanks co-wrote, starred in, and directed That Thing You Do! (1996).

Julia Roberts appears with Meryl Streep's daughter, Grace Gummer, in this film. Roberts would then go on to work with Streep in August: Osage County (2013).

This is the ninth Julia Roberts film with a music score composed by James Newton Howard.

Rami Malek and Grace Gummer both went on to star in Mr. Robot (2015), as Elliot Alderson and Dominique DiPierro, respectively.

Malcom Barret's character, talks about Star Trek. George Takei, famous for its rol as Mr Zulu in the Original Star Trek series, has a rol in this movie.