Demetrius Shipp Jr.'s father produced "Toss It Up" for Tupac Shakur's "The Don Killuminati: The 7 Day Theory" album.
John Singleton was originally attached to direct the film, but the studio and Singleton couldn't agree on how Tupac was to be portrayed in the film. Singleton eventually left the project completely but has since stated that he still hopes to make his own film about Tupac on his own terms some day. He was also the only director to have Afeni Shakur's full blessing to tell her son's story.
On her Twitter account, Jada Pinkett Smith stated that the film contained many inaccuracies about her relationship with Tupac and why he left for Los Angeles. Smith claimed that Tupac never read the poem he read to her character in the film and that she had no knowledge that it even existed until it was published in his book. She also stated that she never attended one of Tupac's shows at his request and that there was no backstage argument. She did, however, praise the performances of Demetrius Shipp Jr. and Kat Graham.
Benny Boom said in an interview that when he first saw a picture of Demetrius Shipp Jr., he thought it was a photo of Tupac himself.
Both Sean Combs and Marion 'Suge' Knight gave blessings to the film, praising their selective portrayals.
The teaser trailer was released on June 16, 2016 - what would have been Tupac Shakur's 45th birthday.
Demetrius Shipp Jr. said in an interview with Snoop Dogg that it had been his dream to do what Tupac did since his father, Demetrius Shipp Sr., had been working with Death Row Records.
The movie is named after Tupac Shakur's album "All Eyez On Me", which was originally released on Feburary 13th, 1996.
This marked Lauren Cohan and Danai Gurira's first collaboration outside of The Walking Dead (2010).
Tupac's rap group, Outlawz, are in several scenes in the film. The two remaining members of the actual Outlawz, Rufis "Young Noble" Cooper and Malcolm "E.D.I. Mean" Greenridge appear as themselves in several scenes with Tupac throughout the film, and even have a couple of speaking parts. Kastro and Napoleon do not appear as themselves in the movie and their roles are played by actors. The remaining members of the Outlaws are now deceased along with Tupac (Hussein Fatal, Yaki Kadafi, and Mussolini respectively).
The second teaser trailer came out twenty years exactly after Tupac Shakur's death.
Anthony Mackie and Marcc Rose have also portrayed 2Pac. Mackie in Notorious (2009) while Rose had a smaller role in Straight Outta Compton (2015).