When Deckard is struggling to free himself as the hovercar fills with water, his hair alternates between dry and wet, even after he puts his head underwater.
The back of K's jacket gets dirty during the fight before reaching the orphanage and then is completely clean when inside the orphanage.
The TRITIUM radiation of the wooden horse figurine (the Trojan Horse) leads blade runner KD6-3.7 (Joe) directly to where Deckard has been hiding, but Deckard has been on the run and was already in hiding long before the birth event on 10th June 2021. So exactly how did the child being chased when at the orphanage, get the wooden horse figurine, and subsequently hide it? Either someone else transported the wooden horse figurine from Deckard to the orphanage, or perhaps Deckard left the wooden horse figurine with pregnant Rachael (N6FAA52318) as a unique gift for their child, or there is a large plot hole here.
While exploring the abandoned casino, K gives a casual one-handed spin to a roulette wheel. The soundtrack adds the rattling noise of a roulette ball (or pill) landing in a pocket, even though K clearly does not pick up a ball or launch one. Only about two-thirds of the wheel is seen before K spins it, so the ball could have been sitting in the non-visible third ; and the camera quickly cuts away, so it could not be seen flung out and spinning.
While examining lady's skeleton in the LAPD morgue, Coco directly states that the person had died more than 30 years ago. The movie takes place in 2049, thus the lady must have died prior to 2019 when the first installment of the "Blade Runner" takes place, making it impossible the skeleton to be of Rachel - Rachel was the part of the first movie and she gave the birth in 2021, according to this movie.
When Luv takes K to the room where the data files are stored, the heavy door jams about half way when opening. She then uses physical strength to open it with her hands (with no apparent effort), but she is wearing elegant shoes with heels on a slippery floor. It would be physically impossible for her to apply enough force on the heavy door to open it without having a good grip on the ground, regardless of her superhuman strength. She would normally slide away when trying.
The first song listed ("Summer Wind"), is displayed as "Perfromed by Frank Sinatra" instead of "Performed by Frank Sinatra".
The forensic autopsy of Rachael's bones mentioned that she died during childbirth BUT it was also mentioned that the bones were 30 years old in 2049 which makes Rachael's death occur in 2019. This makes the 6-10-21 inscription on both the wooden horse and Sapper's tree contradictory to the forensic findings in police morgue/lab.
Replicants are always told to look up and to the left, but they always look up and to their right, when revealing the serial number on their eyeball.