When development for either a live-action film or TV series began when the first book came out in 1997, Dav Pilkey wanted Chris Farley to play Captain Underpants. However, Farley tragically passed away, and the project was shelved.

The last DreamWorks Animation film to be distributed by 20th Century Fox before Universal Pictures took over.

Released on the year of the book series' 20th anniversary.

In the first book, one of the pranks that George and Harold pull is having the PA system in the school playing "Weird Al" for six hours. The film's theme song is sung by none other than "Weird Al."

This is the sixth Dreamworks movie to be adapted from a children's book, the first five being Shrek (2001), How to Train Your Dragon (2010), Rise of the Guardians (2012), Home (2015), and The Boss Baby (2017).

This will be Dreamworks Animation's 31st film adaption.

Ed Helms' 2nd Dreamworks Animation Film, after Monsters vs. Aliens (2009).

The school around which the film's actions are centered is named "Jerome Horwitz Elementary." Jerome Horwitz is the birth name of Curly Howard.

This will be DreamWorks' first superhero movie since Megamind (2010).

This movie will be based on several of the Captain Underpants books by Dav Pilkey.

This will be Nick Kroll's third animated movie since Sausage Party (2016) and Sing (2016).

First film adaptation of a Dav Pilkey book.

Kevin Hart and Ed Helms previously starred together in Meet Dave (2008).

This will be the second time Kevin Hart is a voice in an animated movie. His first time was in The Secret Life of Pets (2016).

Unlike all of the previous DWA films, which were animated in-house in Los Angeles, this is the first DWA film to be outsourced. Instead, the animation was done in a lower budget in Montreal.

The title for the film says The First Epic Movie, despite no sequel has been announced yet. This is because the books had the subtitles "The First, Second, Third, etc. epic novel" under the titles.

The animation for this film was considered similar to The Peanuts Movie (2015), another film distributed by 20th Century Fox.

The plot seems to combine the stories of the first four books.

In the novel, Professor Poopypants' real name is Pippy Pee-Pee Poopypants. This is changed in the film to the even ruder Pee-Pee Diarrheastein Poopypants.

Kevin Hart, Ed Helms, Nick Kroll, and Kristen Schaal each did voice work at Illumination.

The shot of the school children marching sadly into school in the rain matches the shot in Joe Versus the Volcano of workiers marching slowly in the rain into a factory.

David Soren, the director of Turbo (2013), will be directing the movie.

First, and official, trailer for the film released the day after the DVD release of Nick Kroll's previous animated film, Sing (2016), where he also spoke with a German accent.

The second collaboration of Ed Helms and Nick Kroll, the first being Vacation (2015), which featured Peele's on-and-off partner Keegan-Michael Key.

Thomas Middleditch and Kristen Schaal have also done voice work on animated Disney shows.

Released five years after Ed Helms's first animated movie, The Lorax (2012), which was also based on a children's book.

This is the first film from DreamWorks Animation to show the title of the movie at the very end.

During the Flip-O-Rama segment, as Harold steps on the book pages, his footprints leave marks that closely resemble the guide areas in the actual Captain Underpants books, in which the reader places their hands in order to properly flip through the pages.

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