When development for either a live-action film or TV series began when the first book came out in 1997, Dav Pilkey wanted Chris Farley to play Captain Underpants. However, Farley tragically passed away, and the project was shelved.

The last DreamWorks Animation film to be distributed by 20th Century Fox before Universal Pictures took over.

Released on the year of the book series' 20th anniversary.

In the first book, one of the pranks that George and Harold pull is having the PA system in the school playing "Weird Al" for six hours. The film's theme song is sung by none other than "Weird Al."

This is the sixth Dreamworks movie to be adapted from a children's book, the first five being Shrek (2001), How to Train Your Dragon (2010), Rise of the Guardians (2012), Home (2015), and The Boss Baby (2017).

This will be Dreamworks Animation's 31st film adaption.

The school around which the film's actions are centered is named "Jerome Horwitz Elementary." Jerome Horwitz is the birth name of Curly Howard.

Ed Helms' 2nd Dreamworks Animation Film, after Monsters vs. Aliens (2009).

This movie will be based on several of the Captain Underpants books by Dav Pilkey.

Unlike all of the previous DWA films, which were animated in-house in Los Angeles, this is the first DWA film to be outsourced. Instead, the animation was done in a lower budget in Montreal.

This will be DreamWorks' first superhero movie since Megamind (2010).

First film adaptation of a Dav Pilkey book.

This will be Nick Kroll's third animated movie since Sausage Party (2016) and Sing (2016).

Kevin Hart and Ed Helms previously starred together in Meet Dave (2008).

This will be the second time Kevin Hart is a voice in an animated movie. His first time was in The Secret Life of Pets (2016).

The title for the film says The First Epic Movie, despite no sequel has been announced yet. This is because the books had the subtitles "The First, Second, Third, etc. epic novel" under the titles.

The animation for this film was considered similar to The Peanuts Movie (2015), another film distributed by 20th Century Fox.

The plot seems to combine the stories of the first four books.

The shot of the school children marching sadly into school in the rain is an homage to the shot in Joe Versus the Volcano of workers marching slowly in the rain into a factory; a scene which in turn references the great Sci Fi classic Metropolis, in which workers march like clockwork automatons into the factory.

Kevin Hart, Ed Helms, Nick Kroll, and Kristen Schaal each did voice work at Illumination.

David Soren, the director of Turbo (2013), will be directing the movie.

First, and official, trailer for the film released the day after the DVD release of Nick Kroll's previous animated film, Sing (2016), where he also spoke with a German accent.

Ed Helms and Leslie David Baker use to star in _The Office_ together.

The second collaboration of Ed Helms and Nick Kroll, the first being Vacation (2015), which featured Peele's on-and-off partner Keegan-Michael Key.

Released five years after Ed Helms's first animated movie, The Lorax (2012), which was also based on a children's book.

Dreamworks Animation's 9th Film to simply take the name of the Main Protagonist(s), after Shrek (2001), Spirit: Stallion of the Cimarron (2002), Sinbad: Legend of the Seven Seas (2003), Megamind (2010), Puss in Boots (2011), Turbo (2013), Mr. Peabody & Sherman (2014), and The Boss Baby (2017).

Thomas Middleditch and Kristen Schaal have also done voice work on animated Disney shows.

From the Studio That Brought You "Shrek", " Kung Fu Panda" and "Madagascar".

During the Flip-O-Rama segment, as Harold steps on the book pages, his footprints leave marks that closely resemble the guide areas in the actual Captain Underpants books, in which the reader places their hands in order to properly flip through the pages.

In the novel, Professor Poopypants' real name is Pippy Pee-Pee Poopypants. This is changed in the film to the even ruder Pee-Pee Diarrheastein Poopypants.

Melvin is the 7th Character in a Dreamworks Animation film to be a Hidden Secondary Antagonist, where he changes over to the side of the Villains. The previous 6 films where someone does something like that are Shark Tale (2004) with Lola, Shrek the Third (2007) with Rapunzel, Puss in Boots (2011) with Humpty Dumpty, Turbo (2013) with Guy Gagne, How to Train Your Dragon 2 (2014) with the Muddy Bewilderbeast, and Trolls (2016) with Creek.