The scene where Jake follows the Russian to a JFK campaign speech utilized actual audio from the speech JFK gave that day, in that location. The speech and location was heavily photographed in 1960, and was recreated near perfectly.
The opening credits changed slightly every week, reflecting Jake's changes to the time line and/or foreshadowing events in the episode.
The story that Jake tells Mimi is taken from the films The Godfather: Part II (1974) and The Godfather: Part III (1990).
In the first episode Jake (James Franco) makes a reference to Stephen King's Misery (1990), "I'm his number one fan!"
The car that Sadie Dunhill gets into during the first episode is the same red 1958 Plymouth Fury that the movie and book Christine (1983) were based on. Plymouth did not make a red Fury in 1958.
The scenes involving the diner were shot in Guelph, Ontario, Canada at the corner of Oliver and Huron Street. A fake diner was constructed there.
In the final episode 'Redrum' is painted on a wall inside the book depository, a reference to The Shining.
The date of November 22 is tied to other time travel stories as well. Back to the Future Part II (1989) premiered on November 22, 1989, First Contact (1996) premiered on November 22, 1996, and Doctor Who (1963) premiered the day after, on November 23, 1963, although it didn't get much of an audience, on account of the Kennedy assassination the day before.
Annette O'Toole (Edna Price, episode 2) played Beverly Marsh in 1990's Stephen King's It (1990). In the Book 11.22.63 Jake meets Beverly and Richie from It in Derry which in the series is replaced by Holden.
Jonathan Demme was originally going to write, direct and produce a film version of the novel. But he left the project after disputes with Stephen King.
In the Stephen King novel which serves as the basis for the TV show, the main character travels back to 1958. In the show the rabbit hole takes him to 1960.
Another one of the many references to other Stephen King books and movies: one of the stores visible on the Main Street in Lisbon, Maine, is Blue Ribbon Laundry--also the name of the business where Margaret White (mother of Carrie) worked in the novel Carrie.
The Hertz ID created by Al and given to Jake in episode 1 is a reference to the Hertz Rent-A-Car sign atop the Texas school book depository at the time of the assassination. For some reason the producers didn't recreate the sign atop the TSBD for the series.
James Franco says "so good" when asked how the pie tastes, which is a Spider-Man 3 reference of the same dialogue
James Franco is a producer for this series in addition to playing the lead character, Epping.
Several scenes, including the car yard, diner and men's clothing store, were shot in Dunnville, Ontario.
When Jake Epping walks into the motel in the first episode the Nixon-Kennedy debate is on in the background.
Kevin J. O'Connor (Yellow Card Man) also had a role in Peggy Sue Got Married, another movie in which the protagonist time-travels back to the early 1960s and attempts to fix the course of the future.
The name "George" comes up several times during the series. In the original novel, Jake's assumed name in the past is George Amberson. In this version he keeps his real first name, probably for simplicity.
The western hats seen in the series were made by Smithbilt Hats Inc. located in Calgary, Alberta, Canada.
Daniel Webber is the second non-American actor to play Lee Harvey Oswald. Gary Oldman played the part in JFK (1991).
The red door warehouse scenes were filmed on Dunsmure Street in Hamilton, Ontario near Langton Climate Care on Gage.
Several cast members are connected to Spider-Man. Franco starred as Harry Osborne in all three of the Sam Raimi films with Tobey Maguire and Gadon appeared in 'The Amazing Spider-Man 2' with Andrew Garfield. 'Chris Cooper' played Norman Osborne; Harry's father; in The Amazing Spider-Man 2 (2014). In addition, both Uncle Bens, Cliff Robertson and Martin Sheen, have also both played Kennedy.
Sarah Gadon (Sadie Dunhill) and Joanna Douglas (Doris Dunning) have both appeared together in the TV show 'Being Erica'. They played Katie Atkins and Samantha Strange respectively.
Jake makes money in the past by betting on sporting events to which he already knows the outcome, just like Biff Tannen in Back to the Future Part II (1989).
During the opening credits of some, but not all episodes, a diagram of a serpant eating its own tail is shown in yellow with a black background. This symbol is known as the ouroboros. The ouroboros has several meanings interwoven into it. Foremost is the symbolism of the serpent biting, devouring, or eating its own tail. This symbolizes the cyclic Nature of the Universe: creation out of destruction, Life out of Death.
Nick Searcy plays a character named Deke Simmons in this series. Coincedentally, he portrayed astronaut Deke Slayton in the 1998 miniseries From the Earth to the Moon (1998).