Steve Carell said that Despicable Me 3 may be his last film as the voice of Gru. However, Carell stated that if he was asked to do a cameo in any future Minion sequels, he happily would.

Agnes's voice actress Elsie Fisher from the first and second movies was replaced by Nev Scharrel due to Fisher getting too old for the role.

Trey Parker's first role in a movie targeted to children.

This is the first Illumination Entertainment film to be produced in a 2.35:1 widescreen aspect ratio; all of that company's previous films were produced in 1.85:1.

Alan Tudyk was considered for the role of Balthazar Bratt.

Jenny Slate's third Illumination Entertainment film after The Lorax (2012) and The Secret Life of Pets (2016).

This film will feature Balthazar Bratt as the new villain. Other villains in the Despicable Me franchise have been Vector, El Macho, and Scarlet Overkill. Voiced by Jason Segel, Benjamin Bratt, and Sandra Bullock respectively.

Trey Parker released South Park: Bigger, Longer & Uncut (1999) on June 30, and this movie is being released exactly 18 years later, with him playing as Balthazar Bratt.

The diamond featured in the first trailer is a parody to the Pink Panther diamond.

Actor Benjamin Bratt previously voiced the villain, El Macho, from the previous film Despicable Me 2 (2013) and now the new villain in the film happens to be named Balthazar Bratt.

It is rumored in Universal Studios that this Despicable Me installment is to feature Margo, Edith, and Agnes' real mom.

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