The film reunites Queen Latifah and Jada Pinkett Smith just over 20 years since they co-starred in Set It Off (1996).

Features what is arguably the first demonstration in a feature film of 'grapefruiting' as an oral sexual act.

This is the third film to co-star Jada Pinkett Smith and Larenz Tate. They previously appeared together in Menace II Society (1993) and The Inkwell (1994).

This is the first film to star both Jada Pinkett Smith and Regina Hall. Hall previously portrayed "Brenda" in the Scary Movie (2000) franchise, who was a parody of Smith's character "Maureen" from Scream 2 (1997). Also a part of the Scream franchise is Queen Latifah, who has signed on as an executive producer for Season 3 of Scream: The TV Series (2015).

Regina Hall and Queen Latifah both starred in Scary Movie 3, though they didn't share any scenes together.

The words "Thug Life" is written on the wall of a crude run down motel upon the girls' arrival. "Thug Life" is a sentiment late rapper Tupac Shakur popularized during most of his rap career and even had it tattooed across his stomach. Actress Jada Pinkett-Smith (who portrays Lisa Cooper in the film) and Shakur were childhood friends.

Shipping to cinemas under the pseudonym "Southern Essence".

First film produced, written, directed by and starring African-Americans to cross the $100 million mark.

This is Mike Epps second time in a movie with Tiffany Haddish. About 8 years ago, they were in the movie, Janky Promoters, Starring Ice Cube.

With a relatively modest budget of $19 million, it's less than what co-star Jada Pinkett's husband Will Smith receives on average for just one film appearance.

In the scene where the stars have just entered the club while they were wearing wigs and shades, Dina (Tiffany Haddish) says "Lets set it off". "Set It Off" is the name of a movie that starred Queen Latifah and Jada Pinkett-Smith which was also about four black women, who commit robberies in disguise, usually by wearing wigs and shades . In fact when Dina says that line, the characters played by Queen Latifah and Jada Pinkett-Smith look at each other and share a knowing look.

Homage is paid to Set It Off (1996) which starred Queen Latifah and Jada Pinkett Smith during bar scene. After Ryan's disastrous meeting with Bethany after drinking the absinthe-spiked drinks, the ladies don colorful wigs and enter the local bar. The wigs are the same color and style Latifah, Pinkett-Smith, Vivica A. Fox and Kimberly Elise wore during one of the robberies in Set It Off. And, just before they step onto the dance floor, Tiffany Haddish says "Let's set it off".