Despite the potentially sensitive dialogue surrounding same sex marriage, Lily Tomlin said in an interview on NPR's Fresh Air that the most difficult line for her was when she had to denigrate substitute teachers.

Being her first experience as a lead actress on a TV show, Jane Fonda took acting lessons after noticing she was having a hard time playing a character so sustained in time.

When Frankie tells Grace her secret that she made out with a monkey but then proceeds to explain it was Micky Dolenz from the pop/rock band The Monkees, the closing song played during the credits is "She", sung by Micky Dolenz.

Frankie and Grace's beach house, while supposedly in La Jolla is actually located in Malibu. The address is 31212 Broad Beach Rd.

Both Jane Fonda and Lily Tomlin have played Tina Fey's mother. Fonda was her mother in "This is Where I Leave You" and Tomlin played her mother in "Admission".

It was Marta Kaufman's daughter's idea to have Robert and Sol gay and leaving Grace and Frankie to be together as the starting point to the show.

The four main actors have all worked with Aaron Sorkin. Martin Sheen and Lily Tomlin (The West Wing) Jane Fonda and Sam Waterston (The Newsroom).

Almost every episode has a different director. There have been 22 unique directors as of season 2.

In one episode, Frankie wants to look up a movie with 'Lee Marvin' in it. Jane Fonda was in a movie with 'Lee Marvin' Cat Ballou (1965).

Jane Fonda and Lily Tomlin previously starred together in Nine to Five (1980).

In "The Spelling Bee" (s1e7) a contestant on the spelling bee named "Josiah" is asked to spell the word Fartlek, an ode to Martin Sheen's character on the West Wing "Josiah Bartlet"

In S1E11 "The Secrets," After Frankie witnesses Grace kissing one of Frankie's art student convicts, she jokes that their household is becoming the "best little whorehouse in Texas." The Best Little Whorehouse in Texas (1982) is a film starring Dolly Parton, Jane Fonda and Lily Tomlin's 9 to 5 (1980) costar.

Because Jane Fonda and Lily Tomlin were two of the three stars of the movie Nine to Five, some fans first speculated that the country-style cover of Stealers Wheel's "Stuck in the Middle with You" that appeared in the trailer and which serves as the show's credit sequence theme song was performed by their third Nine to Five costar, Dolly Parton. However, the cover was actually performed by Grace Potter, founder of the rock band Grace Potter & the Nocturnals.

Jane Fonda and Sam Waterston previously appeared together in The Newsroom.

Jane Fonda's first leading role in a television series. She previously appeared in a recurring role on The Newsroom (2012).

When Frankie catches Grace trimming the rug under the table with the chairs stacked on top she asks "Do we have a poltergeist?". The star of that 1983 movie Poltergeist, Craig T. Nelson appears later in the season.

June Diane Raphael and Sam Elliott both appeared on Parks and Recreation as April Ludgate and Ron Swanson's Eagletonian counterparts.

During the third season, Robert (Martin Sheen) gets a lead role in a community theater production of "1776," playing John Adams. In his career, Sheen has often played real or fictional presidents or president-adjacent politicians. Real-life politician roles for Sheen have included John F. Kennedy (in the 1983 TV miniseries Kennedy); Kennedy's brother Robert F. Kennedy (in The Missiles of October); and Nixon administration White House Counsel John Dean (in Blind Ambition). Fictional presidents played by Sheen have included seven seasons as President Josiah Bartlet on The West Wing; the unnamed U.S. president in Medusa's Child; and the sinister Greg Stilson in The Dead Zone.

Jane Fonda's name was also Grace in the movie "Peace, Love and Misunderstanding". Her role was a Free Spirited ex Hippie just like Lily Tomlin's character in "Grace and Frankie".

The car Jane Fonda drives is an Audi S3.

Martin Sheen and Sam Waterston previously appeared together in the 1979 movie Eagle's Wing.

In "The Spelling Bee" (S1:E7), while Sol (Sam Waterson) is watching the spelling bee on TV, the child is asked to spell "subpoena", (a legal term) Sam Waterston was the District's Attorney on Law & Order for years.

Baron Vaughn and Ethan Embry were both in the show "Fairly Legal"

Lily Tomlin starred in The West Wing from 2002-2006, along side Martin Sheen.

Although Lois Hanson plays Martin Sheen's mother, she is only 10 years his senior

Lily Tomlin and Sam Elliott previously appeared together in Grandma (2015).

Both Jane Fonda and Lily Tomlin have shared the on-screen ex-boyfriend of actor Sam Elliot. In Grace and Frankie, Jane Fonda's character, Grace, has previously dated Elliot's character. In the Paul Weitz film Grandma (2015), Elliot plays the ex of Lily Tomlin's character. In both scenarios that have been released within less than a year of each other, it has been decades since the old lovers have last seen each other.