This film is directed and co-written by Shane Black, as a sequel to Predator (1987), Predator 2 (1990), and Predators (2010). Shane Black had played Hawkins in the original film.

Was originally conceived as a reboot of the Predator film franchise, until Shane Black came aboard and confirmed, he will be making a sequel instead, as he wanted to continue to explore the Predator mythology.

After the success of Iron Man 3 (2013), Shane Black was approached by 20th Century Fox with an Iron Man 3-sized budget to direct a new Predator movie, and he couldn't resist.

Shane Black has gone on record stating that he wants this movie to be true to the spirit of the franchise, and be R-rated, saying: "It's an odd thing. Whether Deadpool (2016) helped, is an open question, but I suspect it did. I made a condition of my participation with Predator, that it be the same rating as the first movie, and the first movie was rated R. In other words, I don't want to cut away every time the Predator does something violent. I was watching the American version of The Grudge, which was PG-13, and I remember being so frustrated by the fact that everything that was scary in the Japanese version, they had to cut away from in the PG-13 American version."

Shane Black was cast in the original film, with the intention of him re-writing the script during production, which he didn't want to do, and ended up not having to.

Adrien Brody had expressed interest in reprising his role from Predators (2010).

Arnold Schwarzenegger turned down the opportunity to return as Dutch.

Benicio Del Toro was originally supposed to star, but was replaced by Boyd Holbrook, due to scheduling conflicts.

This marks the sixth time the Predator has appeared in a theatrical release, after Predator (1987), Predator 2 (1990), AVP: Alien vs. Predator (2004), Aliens vs. Predator: Requiem (2007), and Predators (2010).

The slogan in the teaser poster, "You'll never see him coming", is an obvious reference to the Predator's Cloak, but also a nod to Iron Man 3 (2013), which was written and directed by Shane Black, in which the character of The Mandarin notably uses the line, "You'll never see me coming..."

Sterling K. Brown, Thomas Jane, Olivia Munn and Boyd Holbrook have starred in a Marvel movie. Sterling was in Black Panther (2018),Thomas was in The Punisher (2004), Olivia was in X-Men: Apocalypse (2016) and Boyd was in Logan (2017).

Boyd Holbrook and Trevante Rhodes were cut from Song to Song (2017).

The poster of this film has a line, YOU'LL NEVER SEE HIM COMING. This is a quote of The Mandarin, from Iron Man 3 (2013). "And you'll NEVER see me coming". Both movies written and directed by Shane Black.

The Predator, shown in the teaser poster, is actually the Crucified Predator from Predators (2010), identifiable by the damage to its Bio-Mask.