According to the visual effects artists, Ego's planet contains one trillion polygons, and is considered to be the biggest visual effect ever made.

Prop Master Russell Bobbitt had difficulty finding the cassette decks used in the first film, and all of the Sony Walkman headphones they found were broken. Bobbitt contacted Sony to see if they had any available for filming. They didn't, so he eventually created six from scratch.

Dave Bautista's Drax make-up took 90 minutes to apply, down from three hours for the first film. However, he would have to sit in a sauna at the end of the day, to get the make-up off.

James Gunn choreographed and served as the motion-capture model for Groot's dance during the opening credits sequence. It took the visual effects team nearly two years to complete the CG rendering of the scene for the final film.

According to Chris Pratt, the film's script helped him come to terms with the death of his father and helped his son come to terms with his father's job.

In the Guardians of the Galaxy comics, Taserface is a warrior from the cybernetically enhanced race known as The Stark. The Stark are a race that found Iron Man technology that accidentally crashed on their homeworld, and as a result, worship Tony Stark (Iron Man) as their god.

As Groot only communicates with the phrase "I am Groot," in different inflections, James Gunn created a "Groot Version" of the script for him and Vin Diesel, which contained each of Groot's lines in English.

According to James Gunn, Groot always freezes when Drax catches him dancing because he knows Drax disapproves of it. Drax explains that he was attracted to his late wife because she steadfastly did not dance.

Bradley Cooper recorded his lines for Rocket while wearing a motion-capture headpiece in the recording studio, to perfectly synchronize Rocket's voice and facial expressions. In the first film, Cooper only supplied the voice.

Elizabeth Debicki was cast as Ayesha because of her six foot three inch (1.91 meters) height. During filming, she wore platform shoes to increase her height to six feet seven inches (2.01 meters).

In the comics, Mantis was human, and acquired her skills by living with the Kree. James Gunn chose to make her an alien in the film because he wanted Peter Quill to be the only one main character to come from Earth.

Director James Gunn revealed that he and Producer Kevin Feige wanted David Bowie to appear in a cameo before his death on January 10, 2016.

Prop Master Russell Bobbitt created a 1:1 scale model of the ten-inch (25 centimeter) Baby Groot for filming to use as a lighting reference, and sometimes puppeteered against the cast members during filming.

Vin Diesel was able to pull off Baby Groot's high pitched voice on his own. His performance required no digital alterations of any kind.

The sensor that Peter Quill looks at when detecting the extra-dimensional creature, is a modified 1977 Mattel handheld "Electronic Football" game. Selling over one million units, this was one of the hottest items of Christmas 1977. The beep at the beginning was the "touchdown" sound, the other beeps were the sound of ball moving down the field.

The stinkbug that gets eaten in the film was actually made of chocolate and black honey.

In an interview for the film, Karen Gillan explained that Nebula "is a pretty angry woman, with some daddy issues and that, in the second movie, we're going to start to see how much pain her father actually caused her, and we're going to delve right into the relationship with her sister Gamora. I think we might even feel a tinge of sympathy towards her this time."

The idea of self-contained minds spontaneously appearing into existence is called "Boltzmann brains." This is a metaphysical conundrum raised by quantum mechanics, and concludes that in a universe that exists forever, you are more likely to be a "Bolzmann brain" hallucinating reality than a real being.

In the Marvel Cinematic Universe timeline, the film takes place in 2014, three months after Guardians of the Galaxy (2014). It takes place a year after Thor: The Dark World (2013), before or after Captain America: The Winter Soldier (2014), and a year before Avengers: Age of Ultron (2015). Ego arrived on Earth and began his relationship with Meredith Quill in 1980, which took place thirty-eight years after Captain America: The First Avenger (2011), and thirty-two years before The Avengers (2012).

Karen Gillan's make-up took two and a half hours to apply, down from five hours for the first film.

After many rumors, Karen Gillan reprised her role as Nebula without shaving her head.

Vin Diesel recorded Groot's voice for sixteen foreign-language releases of the film, up from six in the first film.

Chris Pratt said that he thought Michael Rooker has the best shirtless scene in the film. He said Rooker's shirtless scene is about showing vulnerability and developing Yondu's character. You learn something about him in the moment, but his own scene was just to show off his body, and didn't really add anything to Peter Quill.

Chris Pratt said that he found the workout regimen for his shirtless scene much easier compared to the first film, because he was already in great shape going into the film. For Guardians of the Galaxy (2014), Pratt was sixty pounds overweight when he started working out. For this film, however, he said he had maintained his buff physique acquired from the first film.

James Gunn previously said that Stan Lee's cameo in this film is one of the four Lee cameos filmed in one day. In addition to this film, Gunn directed two other cameos, one being Doctor Strange (2016), and another one in which he did not specify.

Yondu's replacement, larger head-fin brings the character's look closer to his comic counterpart.

This sequel was announced a week before the release of Guardians of the Galaxy (2014) at San Diego Comic-Con 2014.

The teaser poster is a parody of the cover for The Ramones' album Rocket to Russia.

Gary Oldman, Viggo Mortensen, Christoph Waltz, Christopher Plummer, Max von Sydow, Alec Baldwin, Ron Perlman, Stephen Lang, Arnold Schwarzenegger, Bruce Willis, Robert De Niro, Michael Biehn, Mel Gibson and Liam Neeson were considered for the role of Ego.

In September 2015, James Gunn said in a Facebook post that he wanted to use the Sneepers, an alien race that first appeared in Marvel Comics in 1964, as background characters in the film, but he was advised against it by Marvel's legal department because the name was too similar to "snípur", the Icelandic word for "clitoris". The Marvel legal department later cleared the use of Sneepers in the film, in part because of the entire media coverage Gunn's initial post received.

Laura Haddock (Meredith Quill, Peter Quill's mother) also appeared in Captain America: The First Avenger (2011) as a fan of Captain America.

This is the first feature film shot with Red Digital Cinema's Weapon Dragon 8K digital camera. The camera uses a VistaVision sized digital sensor, based on the 35mm format developed in the 1950s that ran film horizontally rather than vertically for a larger negative.

In an interview, James Gunn said that most of the questions will be answered in this film that remained unanswered in the first.

James Gunn clearly stated that this sequel would not set up Avengers: Infinity War (2018).

James Gunn went on record in an interview that he wants to give Nebula her own spin-off movie.

To make the Ravagers' belts, Prop Master Russell Bobbitt had his team cut the leather themselves, rather than buying existing belts, and then parts from different electronic devices such as radios and cell phones were glued together, to make each belt "a unique piece of art".

Chris Sullivan's Taserface make-up took two and a half to three and a half hours to apply.

According to James Gunn, he wanted John C. Reilly to reprise his role as Nova Corpsman Dey, but couldn't due to scheduling conflicts.

In the comics, Mantis is half-German and half-Vietnamese. She is portrayed in the film by Pom Klementieff, who has a South Korean mother and a French-Russian father.

James Gunn cast Michelle Yeoh in the film as a tribute to 1990s Hong Kong films, of which he is a fan.

Matthew McConaughey was considered to play Ego, but passed on the role in favor of The Dark Tower (2017).

James Gunn said in a Instagram post in August 2017, that Farscape (1999) was one of his all time favorite sci-fi shows. So when he ran into the show's star, Ben Browder, a couple of years ago at the Saturn Awards, he asked him if he'd make a cameo. He thankfully agreed and can be seen as the Sovereign Admiral with Ayesha.

Marvel Studios made a statement regarding the future of the "Guardians" franchise, which said Avengers: Infinity War (2018) will take place four years after this film, which in turn takes place in 2014, three months after Guardians of the Galaxy (2014).

James Gunn brought in fractal artist Hal Tenny to help design Ego's planet form.

This film is part of Chapter Three of Phase Three in the Marvel Cinematic Universe.

The Sovereign designs were based on 1930s Art Deco and 1950s science fiction.

Olivia Jackson, the stunt woman for Nebula on the first movie, suffered traumatic brain injury, and a left arm injury, which led to an amputation, as well as multiple fractures to the left side of her face, which required reconstructive surgery. These injuries occurred when she struck a misplaced camera crane while performing a motorcycle stunt during filming for Resident Evil: The Final Chapter (2016). Coincidentally, Nebula (in this movie and in Vol 1) has a prosthetic left arm and reconstructed left side of her face.

On March 23, 2016, Chris Pratt announced a fundraiser to help support the Lake Stevens' Boys and Girls Club from where he grew up. By donating, you would get a chance to visit Pratt, and eat lunch with him on the set of this film.

Benicio Del Toro, who portrayed the Collector in the first Guardians of the Galaxy (2014), expressed interest in portraying the character again despite Marvel not contacting him about the sequel.

When the character of Ayesha was first introduced in the comics, she was just named "Her" (since she was created as a counterpart to the character Adam Warlock, originally named "Him"). She then took on the name "Kismet,"and then was renamed yet again as "Ayesha." In "Fantastic Four" #11 (by Chris Claremont, Salvador Larroca and Art Thibert) the Four ask her for her name, and she replies: "I have had many, but the most appropriate is Ayesha: She--who must be obeyed!" Both the name "Ayesha" and the sobriquet "She who must be obeyed" are references to the 1880s adventure novel She: A History of Adventure by H. Rider Haggard. The main character of the story was also a priestess named Ayesha (also referred to throughout as "She-who-must-be-obeyed"). The elaborate Art Deco-style costume and production design for this movie's Ayesha is also a nod to the most famous movie adaptation of Haggard's novel, She (1935).

This film was shipped to theaters under the pseudonym "Level Up".

Originally set for a July 2017 release, but was pushed up to a May 5th release.

Glenn Close filmed scenes of Nova Prime Irani Rael, but they were cut out of the film for running time purposes.

The edible yarrow root was designed to resemble enlarged pollen grains, and was made of non-dairy white chocolate.

The license plate on Ego's Ford Mustang Cobra is the same as on James Gunn's high school car.

In the comics, Peter Quill's father is J'Son of Spartax, of the alien Spartoi Empire. In this film, it is Ego the Living Planet, a completely unrelated character. However, in the comics, Ego has had the ability to sire a sibling, Alter-Ego.

The car Ego is driving with Meredith Quill in at the beginning of the film, a 1979 Ford Mustang II King Cobra, is painted in metallic teal-blue and orange, the same colors as his son Peter "Star-Lord" Quill's "Milano" M-Ship.

Groot says "I am Groot" seventeen times throughout the entire film.

The ironic thing about Gamora not enjoying dancing, is Zoe Saldana actually has a deep background in dancing, with Ballet being her first passion.

The film's subtitle is a nod to Star-Lord's Awesome Mixtape Vol. 1 tape from Guardians of the Galaxy (2014).

James Gunn, Sr. and Leota Gunn, parents of James Gunn and Sean Gunn (Kraglin), make cameo appearances in the film.

James Gunn noted that many of the crew from the first film, such as Cinematographer Ben Davis and Production Designer Charles Wood, signed on to work on Doctor Strange (2016). However, due to a late change in production schedule to a November 2015 start, they were unable to work on this film.

This film marks the fifth collaboration between James Gunn and Michael Rooker. The other four films were Slither (2006), Super (2010), Guardians of the Galaxy (2014), and The Belko Experiment (2016), which Gunn wrote.

This film takes place three months after the first, placing the events in 2014. Stan Lee's cameo refers to him being a postman, a potential reference to his cameo in Captain America: Civil War (2016). The events in that film, however, take place in 2016. Alternatively, this may be a reference to his cameo in Fantastic Four (2005), where he played the Baxter Building's mailman, Willie Lumpkin.

This is Michael Rosenbaum's first foray as a Marvel Comics character. He previously played several live action and animated DC Comics characters, including Lex Luthor on the television series Smallville (2001), as well as Wally West/the Flash in several animated television shows and movies.

The VFXperts used a clip of James Gunn dancing for reference during Baby Groot's opening dance sequence.

Cast members Kurt Russell and Sylvester Stallone previously worked together in Tango & Cash (1989).

It has been rumored Guardians of the Galaxy Vol. 3 (2020) will be the last to feature Peter Quill, Gamora, Drax the Destroyer, Rocket Raccoon and Groot and that Guardians of the Galaxy: Vol. 4 will focus on the next generation of Guardians of the Galaxy.

Although he is small, "Groot" is Dutch for "Big". So in essence he is saying "I am Big".

Pom Klementieff also provided her voice for the French version.

In the first scene the Guardians appear in, Peter is holding a device to track the octopus like creature which falls from the sky. That device is actually a 1977 Mattel football (I) electronic handheld game.

First Marvel Cinematic Universe sequel to use a number, rather than a subtitle (in this case, Vol. 2) since Iron Man 3 (2013). All other sequels since Iron Man 3 (2013) have used a subtitle, such as Thor: The Dark World (2013), Captain America: The Winter Soldier (2014), Avengers: Age of Ultron (2015), Captain America: Civil War (2016), Thor: Ragnarok (2017) and Avengers: Infinity War (2018). The only other sequel to use a number rather than a subtitle is Iron Man 2 (2010).

Michael Rosenbaum (Martinex) had auditioned to play Star-Lord in the first movie.

Jeff Goldblum (Grandmaster) and Chris Pratt (Starlord) have both played recurring characters in the Jurassic Park franchise.

Vin Diesel and Kurt Russell previously appeared together in Furious 7 (2015) and The Fate of the Furious (2017).

Michael Rooker and Sylvester Stallone worked together in Cliffhanger (1993), a movie about a mountain climber rescue team set on a snow covered mountain, where their characters start out with a strained relationship. Coincidentally, in this movie when they meet each other, it is snowing, and they are also on bad terms with each other.

Three actors with ties to the Stargate franchise appear in this movie: Kurt Russell starred in Stargate (1994) as Colonel Jonathan "Jack" O'Neil. Michael Rooker appeared in Stargate SG-1: Enemy Mine (2003) as Colonel Edwards. Ben Browder starred as Lieutenant Colonel Cameron Mitchell in seasons nine and ten of Stargate SG-1 (1997), as well as the films Stargate: The Ark of Truth (2008) and Stargate: Continuum (2008).

Kurt Russell and Michael Rooker's second film together. The first was Tombstone (1993).

This is Zoe Saldana's sixth science fiction film.

One of the two back to back honorable mentions of David Hasselhoff's works. In this film his Knight Rider (1982) series is mentioned as an influence to Star Lord as a child. The other film is Baywatch (2017), released in the same month (May 2017). Also he has cameos in both the films.

The only MCU film to take place during one phase (Phase 2) but be a part of another phase (Phase 3).

Mainframe, the Artificial Intelligence Ravager almost resembles a Cyberman from the science fiction TV series Doctor Who (2005). In Doctor Who, the Cybermen are a race of cyborgs fought by the show's title protagonist The Doctor. Karen Gillan (Nebula) starred in that series as Amy Pond, companion of the Matt Smith version of The Doctor, which she played from 2010 - 2012 and again in 2013.

Sylvester Stallone is the second actor from The Expendables (2010) to appear in the Marvel Cinematic Universe. Mickey Rourke was the first, starring in Iron Man 2 (2010).

Dave Bautista was a villain in the James Bond movie Spectre (2015). In this movie, he plays Drax, which was also the name of the main villain in the Bond movie Moonraker (1979).

This film was released the same year as other comic book movies such as Logan (2017), The LEGO Batman Movie (2017), Wonder Woman (2017), Spider-Man: Homecoming (2017), Justice League (2017) and Thor: Ragnarok (2017).

This is Sylvester Stallone's second comic-book movie, after Judge Dredd (1995).

David Hasslehoff played Nick Fury in Nick Fury: Agents of Shield (1998) (TV Movie).

At the start of the movie Kurt Russell who was born in 1951 is seen with Laura Haddock. They end up running into the forest where Kurt Russell kisses her. Then a card comes up that says 34 years later. That would be exactly how many years older Kurt Russell is than Laura Haddock. She was born 34 years after him.

This is the second film in the Marvel Cosmic Universe. The first film is Guardians of the Galaxy (2014).

David Hasslehoff whom cameos as Ego as David Hasslehoff had starred in the Italian Star Wars clone Starcrash (1978) as Simon and David Hasslehoff had played Nick Fury in the TV movie Nick Fury: Agent of Shield (1998) (TV Movie) a decade before Samuel L. Jackson assumed the role in the MCU in Iron Man (2008). Samuel L. Jackon had played Mace Windu in Star Wars: Episode I - The Phantom Menace (1999). Star Wars: Episode II - Attack of the Clones (2002) and Star Wars: Episode III - Revenge of the Sith (2005).

An uncredited Miley Cyrus provided the voice of Mainframe in the extra scene with The Ravagers. In real life, Miley Cyrus dated Patrick Schwarzenegger, son of bodybuilder, actor and politician Arnold Schwarzenegger. Arnold Schwarzenegger is the former rival and best friend of Sylvester Stallone (Stakar Ogord) and Schwarzenegger starred opposite Stallone in The Expendables (2010) and it's sequel and in Escape Plan (2013). Arnold Schwarzenegger had starred opposite Michael Rooker (Yondu) in the futuristic action thriller The 6th Day (2000).

Sylvester Stallone, who plays Stakar Ogord, auditioned for Han Solo in Star Wars: Episode IV - A New Hope (1977) but lost out to Harrison Ford. Both Stakar Ogord (a Ravager) and Han Solo are space pirates. Disney, which bought Star Wars creator George Luca's production company Lucasfilm Ltd., and Marvel Studios later produced and released the spin-off film Solo: A Star Wars Story (2017) which is set after Star Wars: Episode III - Revenge of the Sith (2005) and before Rogue One (2016) and Star Wars: Episode IV - A New Hope (1977) and follows the earlier years of Han Solo (Alden Enrenreich) years before he met Luke Skywalker and how the cocky space pirate first became the Captain of the Millenium Falcon.

Both Karen Gillan and Sylvester Stallone have worked with Jack Black. Jack Black shared a scene with Sylvester Stallone in Demolition Man (1993) which he had the small role of a Wasteland Scrap and Jack Black starred opposite Karen Gillan in Jumanji: Welcome to the Jungle (2017) as Bethany.

This film and "Kong: Skull Island" were both nominated for "Best Visual Effects" at the 2018 Academy Awards. This film's VFX supervisor Guy Williams also worked on Peter Jackson's "King Kong" 12 years prior.

Kurt Russell had auditioned for Han Solo in Star Wars: Episode IV - A New Hope (1977) but lost out to Harrison Ford and he was offered to play Flash Gordon in Flash Gordon (1980) but turned it down due to the film's slapstick carefree nature.

When James Gunn was writing the script for the movie, and proposed the idea of Ego the Living Planet being Star-Lord's father, Marvel had told him that they did not have the rights to Ego, whose rights were with 20th Century Fox, because of his ties to the Fantastic Four and Silver Surfer franchises. Since Gunn did not have any other characters in mind for Star-Lord's father, he had to ask Fox if he could use the character. Fortunately, Fox agreed to let Marvel have Ego, in return for Fox having more creative freedom regarding Negasonic Teenage Warhead's set of superpowers in Deadpool (2016).

Stan Lee's cameo has him discussing previous adventures that include his cameos in other Marvel films. According to Kevin Feige, this was a nod to the popular theory that Lee is a cosmic entity in Marvel: "Stan Lee clearly exists, you know, above and apart from the reality of all the films. So the notion that he could be sitting there on a cosmic pit stop during the jump gate sequence in 'Guardians' was something very fun, it says, 'Wait a minute, he's this same character who's popped up in all these films?'"

One of the end credit scenes shows the Sovereign creating a cocoon of sorts for a new being named "Adam." It is assumed that this refers to the character Adam Warlock.

This film features five mid and post-credit scenes.

The bald aliens with Stan Lee are The Watchers, a race of aliens who appeared frequently throughout Marvel comics in the 1960s, 1970s, and 1980s. Uatu is the Watcher assigned to observe Earth 616, the reality in which the regular Marvel Comics Universe takes place.

Gregg Henry who played Peter's grandfather in the first movie, is the old man behind the wheel of the minivan that just escapes destruction by Ego's plants.

James Gunn wanted to feature cosmic entity and Guardian member Adam Warlock in the film, but decided to keep him for Guardians of the Galaxy Vol. 3 (2020), as he felt this film already had too many characters. Adam is anticipated in an end credits scene.

There was some fan speculation as to whether or not Baby Groot was a reborn version of the original and retained all of his original memories, as is the case in the comic books. James Gunn stated that Baby Groot does not have the original's memories, and is a different creature, meaning the original Groot did actually die in the first film.

At Yondu's funeral, are his old friends and fellow Ravagers, which were Charlie-27, Starhawk, Martinex, and Aleta. In the Marvel comics, all four and Yondu were former members of the Guardians of the Galaxy. Also appearing were Krugarr, an alien sorcerer, who, in the comics, was from another timeline, and was the disciple of Doctor Strange, and Mainframe, an alien female robot, who, in the comics, was a male and an android related to the Vision.

Seth Green makes a cameo as Howard The Duck once again. Unlike his previous cameo, however, this one is not a post-credits scene.

During one of the end credits scene, Quill objects when Teenage Groot calls him "boring". This is the first time that Peter is shown as being able to clearly understand Groot's words without help from Rocket.

Michael Rooker always reads the ending of his scripts first, so he found out at once Yondu's death in the film: "I was like 'What?! (picks up phone) James Gunn!'"

James Gunn described making Ego, Star-Lord's father, as a continuation of exploring the personal side of the Guardians, "If a raccoon could talk and shoot a machine gun, how could that be? Answering that question ended up being the entire foundation of the first film. There's a sadness in these characters. Rocket was an animal experimented upon and torn apart. Groot has far more in common with Frankenstein's monster than with Bugs Bunny. Ego is an even more ridiculous character. But if a planet was alive, how could that be? And how could it father a child? Nova Prime said about Peter's father in the first film that he is something ancient and unknown, and being a cosmic being, alone for eons, is even more lonely than being the universe's sole talking raccoon."

During the end credits, Jeff Goldblum can be seen dancing in his Grandmaster costume. This is a small nod to Thor: Ragnarok (2017). The trailer for Thor: Ragnarok, featuring Goldblum's character, had been conveniently released just a few weeks before the premiere of this movie.

Michael Rooker fell asleep when filming Yondu's eulogy scene.

The characters seen listening to Stan Lee are an ancient space race called The Watchers. The camera pans to one of them, who may be Uatu, a Watcher who first appeared in the Fantastic Four comics. In the original Marvel Comics, Uatu lives on the Blue Area of the Moon, watching all events concerning planet Earth, as well as other parts of the universe, and it is possible to visit him to ask information.

In the sequence where Rocket and Yondu are trying to get Baby Groot to retrieve Yondu's fin, one of the items he mistakenly steals is a cybernetic eye. This is the same eye that Rocket claimed that he "needed" in the first movie before embarking on the final battle.

Ego the Living Planet's original appearance in the Marvel Comics was an actual planet with a giant face; in this film he creates a humanoid avatar to interact with people. In the final battle, the planet starts to feature his face in a few scenes, homaging his comic look.

While traveling via multiple space hops, one of the planets the ship travels past appears to be the Kronan homeworld. This is home to Korg the rock creature, who will be appearing in the Planet Hulk storyline of Thor: Ragnarok (2017). Thor already fought and defeated a "Kronanite" in Thor: The Dark World (2013).

In Guardians of the Galaxy (2014), a cocoon is seen in the Collector's collection. Many speculated this cocoon contained Adam Warlock, who is a member of The Guardians in the comic. James Gunn has since stated the Collector's cocoon does not contain the character, as seen in this film when Adam is revealed in the post-credits sequence.

At the end of the first film as he's flying away, Yondu tells Kraglin he thought, upon meeting his dad, that he was a jackass. In this movie, that's exactly what Yondu yells at Ego just before smashing into him with his ship.

Some of the death decorations used on Yondu's body are U.S. military symbols, as follows: a set of U.S. Air Force/U.S. Army Captain's bars the National Defense Service Medal a U.S. Air Force Missileers pin a U.S. Army Ribbon for Good Conduct a U.S. Air Force Missile Maintenance badge, affectionately known as a "Pocket Rocket". It is worn exclusively on the pocket of Air Force Weapons Specialists who have worked with guided missiles and strategic intercontinental ballistic missile systems (fitting for someone who uses a mechanical arrow).

Ego reveals that he placed a tumor in Meredith's brain, which resulted in her sickness and death. Symbolically, Ego dies the same way, as Groot places a bomb on his brain and activates it.

Ego the Living Planet in this film incorporates characteristics of J'son of Spartax (Peter Quill's father) and a Celestial (an ancient cosmic entity).

Mantis compares the idea of Ego's planet form having people settle on him, as like inviting fleas to live on your body. In Rocket Raccoon #6 published in 2014, Rocket takes a job exterminating giant fleas that have settled on Ego.

Ego identifies himself as a Celestial, in the original Marvel Comics, he is a Cosmic Entity. The Celestials are cosmic race of powerful beings created in 1976 by Jack Kirby, made of pure energy embodied in giant armors, and dedicated to the experimentation, creation, and development of sentient life across the universe. Eson the Searcher made a cameo in Guardians of the Galaxy (2014), appearing during a speech of The Collector (Benicio Del Toro) about Infinity Stones.

Yondu saves Star-Lord's life by putting a mask over his head in space, the same trick Star-Lord did with Gamora in the first film.

As the Ravager ships light up the sky with fireworks at Yondu's funeral, his burning ashes form a trail that eventually reshape into his trademark arrow trail.

Despite the announcement that Nathan Fillion was cast in this film, he never appears in the theatrical version.

The opening battle sequence resembles the first issue of the 2008 comic book, which featured the newly-formed Guardians battling a giant monster from another dimension. In that story, the Guardians were defending a cult called the Universal Church of Truth, which had ties to Adam Warlock. In the film, the Guardians are working for the Sovereign race, who are later revealed to be in possession of Adam Warlock's cocoon. Both the Sovereign and the Church become adversaries of the Guardians.

When Nebula says goodbye to Gamora and leaves as she sets out on her own to kill Thanos, Gamora tells Nebula that they don't know if Thanos can be killed. This hints at Nebula's possible fate in Avengers: Infinity War (2018).

As of 2017, Nebula is the only one of the Guardians in this film to not be a Guardian in the comics.

The song in Yondu's funeral scene is "Father and Son" by Cat Stevens.

The film takes place 4 years before Avengers: Infinity War (2018).

Only the first half of Fleetwood Mac's "The Chain" is used in the movie, not the part used in the trailer.

The flowers used as decoration on Yondu's body before cremation are from the species Gloriosa Superba.

at the end of the movie, during Yondu's funeral, the ribbon seen on the cloth across his eyes is the U.S. Army 'Good Conduct' ribbon, aka the 'Never Got Caught'. The design is different for each service, but it is still red and white.

The film contains homages to Kurt Russell movies: When Ego trains Peter, he has him hold his hands together and make blue lightning. This is very similar to the beginning of Russell's adventure movie Big Trouble in Little China (1986). When Ego's body is regenerating, the last part of his body that forms is the area around his left eye. Russell had played the character Snake Plissken in Escape from New York (1981) and Escape from L.A. (1996), a character who wore an eyepatch over his left eye.

Nebula tries to overrun Gamora with a hijacked spaceship at the cave mouth. Later, Rocket overruns Ego by crashing the spaceship on top of him, a repeat of him overrunning Ronan the Accuser in the first Guardians of the Galaxy (2014). These gags are a homage to the helicopter hangar crash in Terminator 3: Rise of the Machines (2003) where the Terminator uses a flying aircraft and overruns the T-X.

Kurt Russell and Vin Diesel co-starred in The Fate Of The Furious, which was released the same year as Vol.2. In Fate, Diesel's character double-crosses the team, whereas in Vol.2, it is Russell's character that turns on the Guardians.