Hannah's bicycle rack (above back fender) appears and disappears.
When Lockhart hides behind the door after trying to gain access to transfusions flugel, the door in the close-up shot being stopped from closing with his crutch is different.
In Volmer's office, Volmer steps out and Lockhart steals a medical file from the filing cabinet. On Volmer's return, they discuss a locket, which is in Lockhart's hand after previously hanging over a picture. When Volmer returns the locket to its position on the picture, the shot from behind the picture frame shows that the locket is placed with the chain in an asymmetrical position over the elaborate frame. In the next shot, showing the picture from the front, the chain is perfectly symmetrical.
The blood on Lockhart's shirt changes.
When looking at the dental x-rays allegedly of Pembroke, one is from 12 year old with severe dental problems and not a 60 year old man. Baby teeth are present and the adult teeth due to come through are visible.
The protagonist is either an attorney (it's never made clear) or a savvy business executive. Either way, he wouldn't have signed the form that he was given at the front desk without first carefully reading it.
A Plaster of Paris cast does not tolerate being wet, and would disintegrate when placed in the sensory deprivation tank.
The main character breaks his leg and a very old fashioned plaster of Paris dressing is applied. Never used now.
Even though the film was shot in Germany, the English-speaking production team apparently used Google Translate and didn't know compound nouns are written as one word in German. Consequently, the words on the signs leading to various wings should not be split up, e.g. "Transfusionsflügel", not "Transfusions Flügel".
In the beginning of the movie, the car accident is completely inconsistent with its aftermath. The car was too slow for that intense outcome.
When Lockhart's car hits the deer, the car rolls deep into the bush. In the subsequent scene where the damaged reindeer walks back onto the road, the car is right next to the road.
The baron used his serfs for medical experiments in 1814. Serfdom was abolished in Switzerland in 1798, with the introduction of the Helvetic Republic. In the canton Graubünden, where the film is set, it had already virtually ceased to exist in the 16th century.
Since the: "Rütlischwur", early in the 14th century, the Swiss define themselves as a: "single People of brethren". Although some noble families kept their titles from before the foundation of the: "Old Swiss Confederacy" and some were granted nobility for services to foreign monarchs, in Switzerland it was quite uncommon to bear a title. Peerage was finally abolished with the creation of the Helvetic Republic in 1798. Therefore it is highly unlikely that in 1814 a "Baron von Reichmerl" could have existed, performing vicious medical experiments. If Alpine mountains and peerage were required for the background story, it should have placed in France, Italy, Austria or Bavaria.
The uniform of the police officer in the pub is not only from a different part of Switzerland, but the design dates back to the early 80ies, whereas the bank notes that Lockhart offers to the vet have only been issued from 1995.
Even though the plot is set in Switzerland, all supposedly native characters speak "Hochdeutsch", standard German, whereas in Switzerland, Swiss German is spoken. Where it is conceivable that at least some of the staff at the sanatorium are German, the same cannot be said for the entire group of village youth in the pub.
In Switzerland, no car plates have letters, except those showing the canton of origin, here GR for Graubünden.
In Switzerland all train lines are electrified with overhead wires. The train in the entrance sequence of the movie was a diesel train, which is not allowed in Switzerland.
The policeman who shows up in the bar wears a uniform that displays a flag of the Canton of Aargau. This is a very long way away from the Canton of Graubünden where this is set.
Lockhart is introduced to Mr Nair who is originally from Bombay, India. His friend goes on calling Mr Nair "a cheater, as all Brahmins"; to which Mr. Nair replies that it is a compliment for him as a venture capitalist. Although the highest caste in India, Brahmins were traditionally priests and scholars, and never went into trade, which was considered "impure". Also, no one who identifies as a Brahmin would use the name Nair, which is a name of the Vaisyas, the caste of traders and administrators. Being a businessman, it would make more sense that Mr. Nair would be the latter.