The film was originally entitled Rock That Body, before being renamed Rough Night.

Filming took place in Long Beach, California, in October 2016, while the pier restaurants and bars of Hermosa Beach, California, were used as stand-ins for Miami nightlife.

Jillian Bell and Ilana Glazer have previously starred in The Night Before (2015).

Kiwi makes a remark about cooking the dead "stripper", saying it was done in Australia. In fact, this is correct: Marcus Volke, a chef, murdered his transgender girlfriend in a Brisbane apartment in 2014. In an ill thought out plan to conceal her body, he tried to boil her dismembered remains in cooking pots. Volke committed suicide before he was brought to trial.