Henry Cavill grew a mustache in order to play the villain and was expected to shave it off for Justice League (2017) reshoots. However, Paramount would not allow this, meaning Warner Bros had to pay millions to have it digitally removed in post-production, making it the most expensive mustache in movie history.
This film was green-lit several days before the release of Mission: Impossible - Rogue Nation (2015).
Jeremy Renner was expected to return, but couldn't, due of filming on Avengers: Infinity War (2018) and Untitled Avengers Movie (2019).
Jeremy Renner is not in this film, due to his commitment to the Marvel Cinematic Universe.
Christopher McQuarrie is the first director in the franchise to direct more than one film.
Tom Cruise and Ving Rhames are the only actors to appear in all six films. Simon Pegg has been in every movie since Mission: Impossible III (2006).
Rebecca Ferguson is the first actress in the franchise to appear twice in a leading role.
In June 2017, Tom Cruise, Michelle Monaghan, and Simon Pegg arrived in New Zealand to beginning filming scenes. It was Tom Cruise's first time there since filming The Last Samurai (2003).
While filming, Tom Cruise was reported to have fractured his ankle in a stunt where he leaped from a building by a spokesman from Paramount Studios. This injury threatened delaying the release of the film.
Michelle Monaghan third appearance in the MI franchise. She started off in MI:III as Julia. She was uncredited in Ghost protocol.
Henry Cavill is the second lead actor from The Tudors (2007) that appears in the Mission: Impossible franchise. Another is Jonathan Rhys Meyers, who appeared in Mission: Impossible III (2006).
Jeremy Renner and Henry Cavill have both played comic book superhero characters. Renner plays Clint Barton/Hawkeye in the Marvel Cinematic Universe while Cavill plays Clark Kent a.k.a. Superman in the DC Cinematic Universe.
Angela Bassett and Courtney B. Vance have co-starred with Tom Cruise, Bassett in Mission Impossible 6 (2018) and Vance in The Mummy (2017).