Peter Griffin / Stewie Griffin / Brian Griffin / Glenn Quagmire / Tom Tucker / Dr. Elmer Hartman / Carter Pewterschmidt / Captain Seamus / Jake Tucker / Stan Smith / Roger the Alien (voice)
Lois Griffin / Tricia Takanawa (voice)
Chris Griffin (voice)
Meg Griffin (voice)
Cleveland Brown / John Herbert / Bruce the Performance Artist / Consuela / Rallo Tubbs (voice)
Joe Swanson (voice)
Johnny Lawrence / Teen Wolf / Social Media Consultant (voice)
Diane Simmons (voice)
Ben / Daniel LaRusso (voice)
Rick Astley (voice)
Jillian Russell (voice)
The Crimson Blur
Mort Goldman (voice)
Geordi La Forge (voice)
Alice Cooper (voice)
Bryan Cranston (voice)
Benedict Cumberbatch (voice)
Alpha 5 / Blue Ranger / White Ranger (voice)
Felicia Day (voice)
Q (voice)
Worf (voice)
Sam (voice)
Nathan Fillion (voice)
Angela (voice)
William Riker (voice)
Billy Blanks / Golden Dragon (voice)
Monkey Kong (voice)
Guinan (voice)
Roberta Tubbs (voice)
John Wick (voice)
Flash Gordon (voice)
Frank the Pug (voice)
Barack Obama / Erik Estrada / Red Ranger (voice)
Michael Pulaski / Counselor Andy (voice)
Avril Lavigne (voice)
Stan Lee (voice)
Ferris Bueller (voice)
Hayley Smith (voice)
Cameron Frye (voice)
Beverly Crusher (voice)
Jack Jeebs / Krampus (voice)
Uhura (voice)
Michelangelo di Lodovico Buonarroti Simoni / Sasquatch (voice)
Spock (voice)
Ron Perlman (voice)
Boris the Animal (voice) (as Quinn Boyce-Bacon)
Jerome / Cleveland Brown Jr. (voice)
Seven of Nine (voice)
Ellie (voice)
Arnold Schwarzenegger (voice)
Worms (voice) (as Patrick M. Seymour)
James T. Kirk (voice)
Gene Simmons (voice)
Deanna Troi (voice)
Buzz Killington (voice)
Snoop Dogg (voice)
Data (voice)
Paul Stanley (voice)
Patrick Stewart / Jean-Luc Picard (voice)
George Takei (voice)
Magic Mike (voice)
Cheryl Tiegs (voice)
Bonnie Swanson (voice)
Mike Tyson (voice)
He-Man / Thulsa Doom (voice)
Hordak (voice)
RoboCop (voice)
Jigsaw (voice)
Mayor Adam West (voice)
John McClane (voice) (archive sound)
Weird Al Yankovic (voice)
Ash Williams (voice) (archive sound) (uncredited)