The following statement by Darren Aronofsky was released a week before the premiere: "It is a mad time to be alive. As the world population nears 8 billion we face issues too serious to fathom: ecosystems collapse as we witness extinction at an unprecedented rate; migrant crises disrupt governments; a seemingly schizophrenic US helps broker a landmark climate treaty and months later withdraws; ancient tribal disputes and beliefs continue to drive war and division; the largest iceberg ever recorded breaks off an Antarctic ice shelf and drifts out to sea. At the same time we face issues too ridiculous to comprehend: in South America, tourists twice kill rare baby dolphins that washed ashore, suffocating them in a frenzy of selfies; politics resembles sporting events; people still starve to death while others can order any meat they desire. As a species our footprint is perilously unsustainable yet we live in a state of denial about the outlook for our planet and our place on it. From this primordial soup of angst and helplessness, I woke up one morning and this movie poured out of me like a fever dream. All of my previous films gestated with me for many years but I wrote the first draft of Mother! (2017) in 5 days. Within a year we were rolling cameras. And now two years later, it is an honor to return to the Lido for the world premiere. I imagine people may ask why the film has such a dark vision. Hubert Selby Jr., the author of Requiem for a Dream (2000), taught me that through staring into the darkest parts of ourselves is where we find the light. "Mother!" begins as a chamber story about a marriage. At the center is a woman who is asked to give and give and give until she can give nothing more. Eventually, the chamber story can't contain the pressure boiling inside. It becomes something else which is hard to explain or describe. I can't fully pinpoint where this film all came from. Some came from the headlines we face every second of every day, some came from the endless buzzing of notifications on our smartphones, some came from living through the blackout of Hurricane Sandy in downtown Manhattan, some came from my heart, some from my gut. Collectively it's a recipe I won't ever be able to reproduce, but I do know this serving is best drunk as a single dose in a shot glass. Knock it back. Salute!" [Aug. 2017]
Jennifer Lawrence and Darren Aronofsky started dating during the production of this film.
Michelle Pfeiffer admitted to not understanding the script the first time she read it, describing it as "esoteric." However, the actress committed to the project after becoming excited by the character she would be playing.
Paramount canceled the upcoming Friday the 13th film in order to move ahead with this film.
Jennifer Lawrence dropped out of The Rosie Project (2019) in order to work with Darren Aronofsky on this movie.
Jennifer Lawrence got so much into her character that during the climactic scenes, she started hyperventilating and even cracked a rib.
This is the first theatrical film by Darren Aronofsky not to feature actor Mark Margolis in any way.
Actors Brian Gleeson and Domhnall Gleeson, who play the two brothers in the movie, are in fact brothers in real life, as their last names would suggest.
The film received both boos and a standing ovation during its premiere at the Venice Film Festival.
The film was shot using 16 mm film. This is the fourth time Darren Aronofsky has shot a film on this format.
Received an "F" CinemaScore, the worst possible score, which is very rare: Only 19 features have ever received an "F". [Sept. 2017]
'Jennifer Lawrence' helped come up with the idea of her character going barefoot throughout the film to emphasize her character's connection to the house.
Darren Aronofsky said the exclamation point in the title is a reference to the last 30 minutes of the film.
The film cast includes two Oscar winners: Javier Bardem and Jennifer Lawrence; and three Oscar nominees: Ed Harris, Kristen Wiig and Michelle Pfeiffer.
There is a 21 year age gap between Javier Bardem and Jennifer Lawrence, who play a married couple in this film.
Edinburgh educated sculptor Jessica Harrison is the artist whose works are referenced in the film's poster image released on Mothers Day 2017. Aronofsky cited Harrison as an inspiration, especially her 'broken' figurines works.
According to writer/director Darren Aronofsky his inspirations for the film included Luis Buñuel's The Exterminating Angel (1962) and Susan Griffin's 1978 book "Women and Nature".
After filming the scene in which Jennifer Lawrence hyperventilated (and production was put on hold while she was placed on oxygen), members of the crew came up with the idea to make Lawrence her very own "happy place"--a tent complete with gumballs and clips of "Keeping Up with the Kardashians" that play on a constant loop.
First film by Darren Aronofsky not to feature Mark Morgolis. The pair have collaborated on every on of the director's films since his debut with Pi (1998).
'Jennifer Lawrence' met with Darren Aronofsky to hear his ideas before there was a script. After she read the script, she said she was so shaken by it that she threw it across the room.
The release date was originally set for October 13, but it was pushed forward to September 15.
Jóhann Jóhannsson wrote the original score for this movie before it was replaced, according to IndieWire.
With a US box office of only $ 7.5 mill. on the first weekend, this was Jennifer Lawrence's worst wide release opening ever. 
Prior to the start of principal photography the cast rehearsed for three months in a warehouse during which time Aronofsky was able to "get a sense of movement and camera movement, and learn from that".
In the film, there are 11 scenes that are strikingly similar to 11 scenes from the thriller House of Good and Evil (2013)
Darren Aronofsky submitted a written statement about the film when it premiered at the Venice Film Festival, in which he revealed that he wrote the first draft of the script in 5 days ("a fever dream," he called it) and that the idea was inspired by current events, "the endless buzzing of notifications on our smartphones," and his experiences going through Hurricane Sandy in downtown Manhattan. "It is a mad time to be alive," he wrote. He also wrote that the film should be "drunk as a single dose in a shot glass. Knock it back."