This movie is based on how Kumail Nanjiani, and his real life wife (co-writer) Emily V. Gordon, met and fell in love.

The film premiered at the Sundance Film Festival where it was highly well received. Which started a bidding war for the distribution rights between Sony, Focus Features, Amazon, & Netflix. Co-creator of the film, Kumail Nanjiani wanted the film to have theatrical distribution which eliminated Netflix from the bidding war because they're not a proponent in that distribution model. The film's distribution rights were eventually bought for around $12 million by Amazon who is a big proponent of the theatrical experience, with all of its films getting at least some kind of theatrical run. The $12 million dollar deal is one of the largest deals in Sundance's history.

In the film it's mentioned more than once that Kumail is a fan of the TV series, The X-Files. In reality, Kumail Nanjiani actually appeared in an episode of The X-Files in 2016.

Kumail Nanjiani and Emily V. Gordon had a podcast called The Indoor Kids where they discussed video games. The name refers to a line from Wet Hot American Summer which director Michael Showalter co-wrote.

Kumail Nanjiani plays a version of himself in the film, including having the same name. However, his wife, Emily Gordon, has her name changed to Emily Gardner.

In a hospital scene we can quickly see Emily's wrist band which says DOB is 5/3. That is the real birthday of Emily V. Gordon - though different years.

Kumail Nanjiani and Adeel Akhtar are the only two actors in their on-screen family of actual Pakistani origin. The rest of the actors (Anupam Kher, Zenobia Shroff and Shernaz Treasurywala) are all Indian.

In November 2016, Kumail Nanjiani was a guest on the NPR podcast "Pop Culture Happy Hour." When one of the podcast's hosts, Linda Holmes, invited him to plug his upcoming movie (which at the time was still filming), he said, "my wife and I wrote a movie, and I'm in it, and it's going to come out next year. Right now it's called 'The Big Sick,' but the name's going to change. So just look for the rom-com about a brown man and a white woman, starring me."

In a nod to the fact that both the character of Kumail and the real-life Kumail Nanjiani are fans of the television series The X-Files, in this movie, Kumail's cellphone ringtone is the "Theme from The X-Files" by Mark Snow.

This is the Opening Night film for the 2017 Seattle International Film Festival.

Kumail's sister-in-law suggests he should be on 'Saturday Night Live'. Aidy Bryant, who plays Mary, is a current cast member of 'Saturday Night Live'.

It was shown on the closing night of the 3rd Edition (2017) of "IndieBo" (Bogota's Independent Film Festival) as part of the "In Focus" section.

Emily and her mother wear the same necklace through most of the film: it's a gold pendant that has a sun on one side and the word "love" engraved on the other side.

Was released in the U.S.A on Kumail Nanjiani's 10th wedding anniversary.

Emily V. Gordon: co-writer and the "real" Emily can be seen in the last scene of the film in the comedy club sitting near CJ and Mary.

In this movie, when the character of Kumail finally tells his parents that he is (1) in love with Emily; (2) Emily is not Pakistani; and (3) Emily is very (maybe mortally) ill, Kumail's mother immediately shuns him (telling him "you are not my son") and remains quite angry with him for the duration of the movie, only showing a small sign of thawing at the very end of the movie. During an "All Things Considered" interview with the real Kumail Nanjiani and his real-life wife and co-screenwriter, Emily V. Gordon, Nanjiani said that this scene was one way in which his real life was very different from its depiction in this movie--that in reality, when his mother first heard about Emily and her serious illness, she was very concerned and supportive, and it was only once Emily was out of the coma and it was clear that she would recover that Mrs. Nanjiani expressed her anger at Kumail for dating a white woman and for only pretending to be amenable to an arranged marriage to a Pakistani woman. Gordon added that in their real lives, Kumail's mother "never, never once, never came close to her disowning" Kumail.