Rosamund Pike revealed in an interview that she and Christian Bale barely spoke during filming outside of shooting their scenes, saying that Bale "would keep a distance. Our characters in 'Hostiles' are quite dysfunctional but have this profound connection that we let happen without ever really talking about it".

Christian Bale and Rosamund Pike were supposed to work together a year before, in a movie called The Deep Blue Good-By, directed by James Mangold but the project fell through due to Bale's leg injuries. Bale recovered but the project didn't resurface and he teamed up with Pike for this project.

Christian Bale and Ben Foster starred together in another western, 3:10 to Yuma (2007), a decade prior to this film.

Scott Cooper became interested in casting Rosamund Pike after seeing her in the music video Massive Attack: Voodoo in My Blood (2016).

Christian Bale, Stephen Lang and Rory Cochrane previously worked together in Public Enemies (2009).

Rory Cochrane and Jesse Plemons both starred in Black Mass (2015), also directed by Scott Cooper.

This is the second collaboration between Scott Cooper and Jesse Plemons. The previous was Black Mass (2015).

This will be the first time Christian Bale and Scott Cooper worked together since Out of the Furnace (2013).

Christian Bale, Q'orianka Kilcher and Wes Studi also starred in The New World (2005).

This will be the second time Rosamond Pike has worked with a Batman actor. She also worked with Ben Affleck in Gone Girl (2014).