While casting True Romance (1993), which co-stars Michael Rapaport, Jennifer Jason Leigh was offered the role of Alabama Whitman. That role was eventually was given to Patricia Arquette.
Michael Raparort was in an episode of The Big Bang Theory (2007) where he has a very literal and pedantic conversation with Lenard and Sheldon. There are lots of theories of Sheldon Cooper being on the spectrum although this has never been confirmed. In fact Mayim Bialik (Amy and real life neurobiologist) stated that it wasn't important to add the label of autism because it wouldn't change who he is as a person. In this series Doug struggles to come to terms but still treats Sam as if he would any other person neuro-typical or neuro-diverse.