Nick Kroll voices up to twelve characters, including Nick Birch, Maurice the Hormone Monster, and Coach Steve.
When Nick and Jessi are having dinner, their chairs are a reference to Fast Times at Ridgemont High (1982).
Nick Kroll, Mark Duplass, Paul Scheer, Jason Mantzoukas, Neil Casey, June Diane Raphael, Rob Huebel, and Zach Woods all appeared in the show The League (2009-2015).
In Episode 7, "Requiem for a Wet Dream", the character Matthew makes a reference to the TV series "Girls". Andrew Rannells, who voices Matthew, plays a recurring character on "Girls".
Nick Kroll, Fred Armisen, Maya Rudolph, Richard Kind and Paula Pell all appeared or had cameo rolls in another Netflix original series, Unbreakable Kimmy Schmidt.
Jason Mantzoukas, Paul Scheer, and June Diane Raphael are the hosts of the podcast How Did This Get Made, and Nick Kroll was the guest on their first episode.