The boys mention the panels they are going to attend when they are at Comic-Con. The cast members of The Big Bang Theory themselves have appeared in panels at Comic-Con several times.
In the scenes at Bernadette and Howard's house Stuart is seen wearing a gray t-shirt with the Ubuntu Linux distribution logo on it. Appropriately this logo is called 'Circle of Friends'.
When the boys describe Raj's ideal business manager (hinting that Sheldon would be the obvious choice), Sheldon remarks that this person sounds like a sociopath. Leonard adds that they don't know, since his mother never had him tested for sociopathy. This is clearly poking fun at the running joke of Sheldon's repeated assertion that he is not crazy, as his mother had him tested.
Sheldon says that Comic-Con is in four months. Since Comic-Con is always held in July, this episode must take place around March 2017. The episode was aired February 23, 2017.