Nick Birch / Maury the Hormone Monster / Coach Steve Steve / Joe Walsh / Nick Starr (voice)
Andrew Glouberman / Babe the Blue Ox (voice)
Jessi Glaser (voice)
Jay Bilzerian / Ghost of Socrates (voice)
Missy Foreman-Greenwald (voice)
Elliot Birch / Ghost of Antonin Scalia (voice)
Diane Birch / Connie the Hormone Monstress (voice)
Ghost of Duke Ellington / Ghost of Freddie Mercury / Atlanta Clause (voice)
Leah Birch (voice)
Uninterested Girl (voice)
Judd Birch (voice)
Movie Theater Customer (voice)
Dwayne 'The Rock' Johnson (voice)
Marty Glouberman (voice)
DeVon (voice)
Freddie Mercury (singing voice) (as Brendan McCreary)
Greg Glaser (voice)
Barbara Glouberman (voice)
Matthew MacDell (voice)
Caleb (voice)