- Told Nicolas Cage to ignore all of his acting instincts, for his role in Il ladro di orchidee (2002). Cage later received a Oscar Nomination for his acting in that movie.
- Was set to direct Il curioso caso di Benjamin Button (2008) back in 2001, with a release in late 2002 but backed out to work on Il ladro di orchidee (2002).
- One of the most renowned directors for music videos, he has received numerous awards and recognition from MTV for his outstanding work in the medium.
- He is co-owner of the Girl skateboard company.
- Jonze was an avid BMX freestyle rider in his youth.
- Was originally going to direct Synecdoche, New York (2008), but took the role as producer instead, to finish Nel paese delle creature selvagge (2009).
- Before George Lucas decided to make the movie himself, Spike was in talks to direct Star Wars: Episodio II - L'attacco dei cloni (2002).
- Former son-in-law of Francis Ford Coppola.
- Has directed two actors and two actresses to a Oscar Nomination - Catherine Keener (Best Actress in a Supporting Role, Essere John Malkovich (1999)), Chris Cooper (Best Actor in a Supporting Role, Il ladro di orchidee (2002), Meryl Streep (Best Actress in a Supporting Role, Il ladro di orchidee (2002)) and Nicolas Cage (Best Actor in a Leading Role, Il ladro di orchidee (2002). Cooper won the Oscar for his role in Il ladro di orchidee (2002).
- While filming Nel paese delle creature selvagge (2009), Jonze kept in contact with the book's original writer Maurice Sendak, to mix Sendak's ideas with his own.
- Good friends with musician Ye and director David Fincher.
- His close movie-making friends include music-video director Chris Cunningham, Charlie Kaufman, David Fincher, Catherine Keener, Nicole Holofcener, Miranda July, Bennett Miller and Steven Soderbergh.
- Considered directing Memorie di una geisha (2005) but was already in pre-production on Nel paese delle creature selvagge (2009), a pet project of his.
- Grew up with friend and Jackass co-creator Jeff Tremaine.
- Started as a magazine editor and contributor before moving into film.
- Was originally offered the chance to direct Human Nature (2001) after the success of Essere John Malkovich (1999). He considered it, but declined, recommending fellow music video director Michel Gondry for the project.
- Continues to shoot some of the finest films in the skateboarding scene, among these is Blind's 1991 magnum opus "VideoDays" and Girl's 2003 "Yeah Right!".
- Was offered the opportunity to direct the movie Guida galattica per autostoppisti (2005), but declined. He suggested small British production company "Hammer and Tongs", instead.
- His father was from a German Jewish and Russian Jewish family, while his mother's ancestry includes German, Scottish and English.
- As of 2014, has appeared in three films that were nominated for the Best Picture Oscar: L'arte di vincere (2011), Lei (2013) and The Wolf of Wall Street (2013).
- (early 1990s) Featured in a "Spike-Needs-A-Girlfriend" contest in Christina Kelly's 'What Now' column in Sassy Magazine. His requirements for a girlfriend were: "short hair, clear skin and good teeth".
- Was a member of Propaganda Films.
- In 2001, at the age of 32, he directed the video for Fatboy Slim's "Weapon of Choice." This video contains 32 cuts.
- Brother of Sam Spiegel.
- Is not to be confused with famous novelty musician and band leader Spike Jones.
- Contrary to popular belief is not an heir to the Spiegel catalog fortune, although he is a distant relative of those that are.
- Cousin of Gabriel Cowan.
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