Alyssa Milano in Project Runway All Stars (2012)

Alyssa Milano, Isaac Mizrahi, and Georgina Chapman in Project Runway All Stars (2012)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Rebecca Minkoff, and Olivia Culpo in Project Runway All Stars (2012)

Alyssa Milano, Anya Ayoung-Chee, Irina Shabayeva, Seth Aaron Henderson, Anthony Ryan Auld, Dmitry Sholokhov, and Michelle Lesniak in Project Runway All Stars (2012)

Alyssa Milano, Isaac Mizrahi, Kiera Chaplin, Georgina Chapman, and Sofia Carson in Project Runway All Stars (2012)

Alyssa Milano, Debra Messing, Isaac Mizrahi, and Georgina Chapman in Project Runway All Stars (2012)

Alyssa Milano and Debra Messing in Project Runway All Stars (2012)

Alyssa Milano, Mark Dacascos, and Scott Wolf in Double Dragon (1994)

Alyssa Milano, Janeane Garofalo, Adam Scott, Michael Ian Black, Mark Feuerstein, Nina Hellman, Marguerite Moreau, Zak Orth, Amy Poehler, Marisa Ryan, and Jai Courtney in Wet Hot American Summer: Ten Years Later (2017)

Alyssa Milano in Wet Hot American Summer: Ten Years Later (2017)

Alyssa Milano and Marguerite Moreau in Wet Hot American Summer: Ten Years Later (2017)

Alyssa Milano, Adam Scott, Michael Ian Black, Marguerite Moreau, and Marisa Ryan in Wet Hot American Summer: Ten Years Later (2017)

Alyssa Milano and Michael Ian Black in Wet Hot American Summer: Ten Years Later (2017)

Alyssa Milano, Tony Danza, Katherine Helmond, and Judith Light in Television (1988)

Alyssa Milano and Arnold Schwarzenegger in Commando (1985)

Alyssa Milano in All the World's a Runway (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, and Andrea Riseborough in All the World's a Runway (2019)

Alyssa Milano, Isaac Mizrahi, Andrea Riseborough, Irina Shabayeva, Dmitry Sholokhov, Michelle Lesniak, and Anne Fulenwider in All the World's a Runway (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Andrea Riseborough, Evan Biddell, Irina Shabayeva, Dmitry Sholokhov, Michelle Lesniak, and Anne Fulenwider in All the World's a Runway (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Andrea Riseborough, and Irina Shabayeva in All the World's a Runway (2019)

Alyssa Milano, Georgina Chapman, and Dmitry Sholokhov in All the World's a Runway (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Nina Garcia, and Iris Apfel in Nina Says Don't Cry Over Spilt Silk (2019)

Alyssa Milano in Nina Says Don't Cry Over Spilt Silk (2019)

Alyssa Milano in Climate Quick Change (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, Reem Acra, and Cynthia Erivo in Climate Quick Change (2019)

Alyssa Milano, Isaac Mizrahi, Georgina Chapman, and Asia Kate Dillon in Project Runway All Stars (2012)

Alyssa Milano, Rose McGowan, and Holly Marie Combs in Charmed (1998)

Alyssa Milano, Rose McGowan, Holly Marie Combs, and Shannen Doherty in Charmed (1998)

Drew Barrymore, Alyssa Milano, Tom Skerritt, Belinda Bauer, Cheryl Ladd, Camilla Belle, Sara Gilbert, Jaime Pressly, Xander Berkeley, Megan Edwards, and Greg Vaughan in Poison Ivy (1992)