Tommy Lee Jones, Kevin Kline, Woody Harrelson, Virginia Madsen, John C. Reilly, Meryl Streep, Lily Tomlin, Garrison Keillor, Lindsay Lohan, and Maya Rudolph in A Prairie Home Companion (2006)

Julianne Moore, Mark Wahlberg, Don Cheadle, William H. Macy, John C. Reilly, Burt Reynolds, Heather Graham, Luis Guzmán, and Nicole Ari Parker in Boogie Nights (1997)

John C. Reilly and Joaquin Phoenix in The Sisters Brothers (2018)

John C. Reilly and Steve Coogan in Stan & Ollie (2018)

John C. Reilly, Joaquin Phoenix, Jake Gyllenhaal, and Riz Ahmed in The Sisters Brothers (2018)

Ralph Fiennes, John C. Reilly, Will Ferrell, Rob Brydon, Steve Coogan, and Rebecca Hall in Holmes & Watson (2018)

John C. Reilly, Steve Coogan, Shirley Henderson, and Nina Arianda in Stan & Ollie (2018)

John C. Reilly and Will Ferrell in Holmes & Watson (2018)

John C. Reilly in The Sisters Brothers (2018)

Jodie Foster, John C. Reilly, Kate Winslet, and Christoph Waltz in Carnage (2011)

John C. Reilly and Andy Hirsch in Winning Time: The Rise of the Lakers Dynasty (2022)

Sally Field and John C. Reilly in Winning Time: The Rise of the Lakers Dynasty (2022)

John C. Reilly and Adrien Brody in Winning Time: The Rise of the Lakers Dynasty (2022)

John C. Reilly, Brett Cullen, and Jason Segel in Winning Time: The Rise of the Lakers Dynasty (2022)

John C. Reilly in Winning Time: The Rise of the Lakers Dynasty (2022)

John C. Reilly and Michael Chiklis in Winning Time: The Rise of the Lakers Dynasty (2022)

John C. Reilly, Stephen Adly Guirgis, and Shaylaren Hilton in Winning Time: The Rise of the Lakers Dynasty (2022)

John C. Reilly and Quincy Isaiah in Winning Time: The Rise of the Lakers Dynasty (2022)

John C. Reilly, Kirk Bovill, and Quincy Isaiah in Winning Time: The Rise of the Lakers Dynasty (2022)

John C. Reilly, Stephen Adly Guirgis, Jason Clarke, and Brett Cullen in Winning Time: The Rise of the Lakers Dynasty (2022)

John C. Reilly, Fred Armisen, and Tim Heidecker in Beef (2020)

John C. Reilly, Fred Armisen, and Tim Heidecker in Move the Base (2020)

John C. Reilly and Fred Armisen in Moonbase 8 (2020)

John C. Reilly, Will Ferrell, Michael Clarke Duncan, Leslie Bibb, and Sacha Baron Cohen in Talladega Nights: The Ballad of Ricky Bobby (2006)