Christina Applegate and Kevin Mangan in Mars Attacks! (1996)

Harrison Ford, Christina Applegate, and Will Ferrell in Anchorman 2: The Legend Continues (2013)

Christina Applegate in Web Therapy (2011)

Christina Applegate and Nina Dobrev in Crash Pad (2017)

Christina Applegate, Thomas Haden Church, and Nina Dobrev in Crash Pad (2017)

Christina Applegate in Tilt-A-Whirl (2005)

Christina Applegate and Conan O'Brien in Conan (2010)

Christina Applegate and Matthew Perry in Dance 'Til Dawn (1988)

Christina Applegate and Linda Cardellini in We've Been Here Before (2022)

Christina Applegate and Linda Cardellini in Where Do We Go Now? (2022)

Christina Applegate in Saturday Night Live (1975)

Christina Applegate and Matt LeBlanc in Married... with Children (1987)

Christina Applegate, Will Ferrell, and Fred Willard in Anchorman: The Legend of Ron Burgundy (2004)

Christina Applegate in Married... with Children (1987)

Christina Applegate and Linda Cardellini in Dead to Me (2019)

Christina Applegate, Joe Don Baker, Lukas Haas, Jack Black, O-Lan Jones, and Sylvia Sidney in Mars Attacks! (1996)

Cameron Diaz, Christina Applegate, and Selma Blair in The Sweetest Thing (2002)

Christina Applegate in The Giving Tree (2000)

Matt Dillon, Christina Applegate, and Steve Zahn in Employee of the Month (2004)

Christina Applegate, Will Ferrell, Steve Carell, David Koechner, and Paul Rudd in Anchorman: The Legend of Ron Burgundy (2004)

Christina Applegate in Suzanne's Diary for Nicholas (2005)