She (along with actresses Tangi Miller and Alyson Hannigan) is a spokesperson for breast cancer, and will appear in a new four page brochure (to be featured in Vogue, Glamour, Self, Mademoiselle, and Women's Sports and Fitness) to raise awareness about the disease. [May 2000]
Education: Professional Children's School N.Y. Coached by the great Ernie Martin.
Daughter of David Combs and Lauralei Combs.
Hobbies include gardening and horseback riding.
Pets: 3 horses (Jake, Jezebel, and Jesse), 4 fish (all nameless), 4 birds (only two of which are named, Lollie and Flower), 6 dogs (Travis, Hugo, Sugar, Thunder, Lola, and Fly Guy), 2 Cats (Blue and Selena), and 2 rabbits (Thumper and Jack). The cats and rabbits are the only pets that live indoors.
Was engaged to Storm Lyndon but they split up late in 2000.
Was a bridesmaid at the wedding of Alyssa Milano. 
#62 in FHM's 100 sexiest women countdown. 
#78 in Stuff magazines 103 sexiest women countdown. 
Married Charmed (1998) key grip David W. Donoho on February 14, 2004.
Upon Shannen Doherty's departure from Charmed (1998), Holly Marie Combs' character Piper became the oldest sister, despite being the youngest of all four actresses who have played Halliwell sisters in the series.
The scar in her eyebrow was caused by her walking into a marble table when she was learning to walk.
Her mother had her when she was only 15.
Her favorite books include, "The Garden of Eden" by Ernest Hemingway and "Practical Magic" by Alice Hoffman.
She is a huge Remy Zero fan.
Was the only cast member of Charmed (1998) to want the show to continue.
Enjoys horror movies.
Filmed an unaired pilot called Rockenwagner.
Is good friends with Charisma Carpenter.
Although not credited she was in a back room poker game scene with Rusty (played by Brad Pitt) in "Ocean's Eleven" where she was addressed by her real name.
Best known by the public for her roles as Kimberly Brock on Picket Fences (1992) and as Piper Halliwell on Charmed (1998).
Her acting mentor was: Tom Skerritt.
Mother, with ex-husband David W. Donoho, of sons Finley Arthur Donoho (b. April 26, 2004 via C-section), Riley Edward Donoho (b. October 26, 2006 via C-section) and Kelley James Donoho (b. May 26, 2009 5 weeks premature via emergency C-section).
Has been cast in Sees Me Through as Dr. Cody Black. [February 2010]
Has just been cast in Sees Me Through as Dr. Cody Black. [February 2010]
Is only 15 years older than Lucy Hale who plays her daughter on Pretty Little Liars (2010).
Is of Irish descent.
In 2016, she met restauranteur Mike Ryan at his Los Angeles restaurant Xoc. On September 3, 2017, Combs announced their engagement on her official Instagram account, sharing a picture of an oval-cut diamond ring. On September 7, 2019, they were married in Carmel, California.
Has a step-daughter (b. 2002).