Graduated from Kent School in 1966, the same high school Peter Farrelly, Sebastian Siegel, Treat Williams and Seth MacFarlane attended.
Has heard one of his more famous characters, "Dr. John Becker," described by a fan as "the American Medical Association's answer to Basil Fawlty." Danson completely agrees with this sentiment.
Danson appeared in episodes of the same three different series with both John Mahoney and Kelsey Grammer: Cheers (1982), Frasier (1993) and Becker (1998), although only in Frasier (1993) did Mahoney and Grammer play their signature roles of Martin and Frasier Crane, respectively.
Played Jason Ritter's father in Mumford (1999). His wife Mary Steenburgen played Ritter's mother in Joan of Arcadia (2003).
Said in a TV interview that his daughter was on the set during the scene from Creepshow (1982) where his character returns from the dead encased in rotted flesh and seaweed. He purposely tried avoiding his young daughter out of a fear of scaring her. Finally, despite his best efforts, she went up to him, looked at him and simply said, "Oh, Hi Dad".
President Bill Clinton and First Lady Hillary Clinton attended his 1995 wedding to Mary Steenburgen. Steenburgen had personally known Clinton since he was governor of Arkansas when she resided in Little Rock. The President celebrated his 51st birthday at the Martha's Vineyard home of the couple.
Father of actress Kate Danson and Alexis Danson (adopted 1987). Father-in-law of Jesse Bochco.
Appeared on the cover of GQ magazine three times: September '84, August '88 and July '93.
Danson played Sam Malone in three different series: Cheers (1982), The Simpsons (1989) and Frasier (1993). He was one of the 3 actors who appeared in all 271 episodes of Cheers (1982). He chose to leave Cheers (1982), after 11 seasons as he was tired of playing Malone and the producers chose to end the series. He played the role for the last time on the spin-off series, Frasier (1993).
He has English, Scottish, and smaller amounts of Scots-Irish (Northern Irish) and German, ancestry. His paternal grandfather was born in England.
He has played the same character (D. B. Russell) in three different series: CSI: Crime Scene Investigation (2000), CSI: NY (2004) and CSI: Cyber (2015).
He and Stephen Colbert are distant relatives, as revealed on the PBS series, Finding Your Roots with Henry Louis Gates, Jr.: Puritans and Pioneers (2017).
As of 2018, has appeared in one film nominated for Best Picture Oscar (Saving Private Ryan (1998)).
Nominated for the 2018 Emmy Award in the Lead Actor in a Comedy Series category for his role as Michael in The Good Place (2016), but lost to Bill Hader from Barry (2018).