- Typically does his own thorough research for his roles, not trusting advisers or coaches.
- Despite being left-handed, he was so dedicated to playing right-handed astronaut Alan Shepard in The Right Stuff (1983), that he used his right hand for writing and other important actions on-screen.
- Once an opponent of the death penalty, he converted to supporting it after briefly listening to an audio tape of the torture and murder of two teenage girls while preparing for his role in The Silence of the Lambs (1991).
- Did 2,000 push-ups (at one time) on the set of Urban Cowboy (1980).
- In preparation for the filming of Backdraft (1991), he rode along with the firemen in the Chicago area and was injured when exposed to active fire.
- Received a BA in English at William & Mary College.
- As of 2014, has appeared in four films that were Oscar nominated as best Picture: Nashville (1975), Apocalypse Now (1979), The Right Stuff (1983) and The Silence of the Lambs (1991), which won in the category.
- Spent five months as a reporter for a newspaper in Kenosha, Wisconsin before he started acting.
- His role in Sucker Punch (2011) was written specifically for him by writer/director Zack Snyder.
- Was a close friend of Toshirô Mifune.
- As a former member of the United States Marine Corps, he is the only actor playing a member of the Bush administration in W. (2008) who has actual military experience (in addition to the director Oliver Stone).
- He had initially wanted to be an author but found that he had trouble writing dialogue. To learn more about it, he began taking acting classes and then started acting.
- Had been friends with Zack Snyder years before working with him on Sucker Punch (2011).
- Father, with Carol, of two girls named Dakota Glenn (Dakota Ann Glenn), a writer, and Rio Glenn (Rio Elizabeth Glenn), an actress.
- He has Irish and Native American ancestry.
- Scott converted to Judaism in the 1960s, when marrying his wife, Carol.
- Served in the United States Marine Corps in the early 1960s in the 173rd Airborne Brigade.
- In response to an AFI survey, Glenn named Ashes and Diamonds (1958) as his favorite film of all-time.
- Is one of three actors to play Jack Crawford in the Hannibal Lecter films. He played the role in The Silence of the Lambs (1991), while Dennis Farina played the role in Manhunter (1986), and Harvey Keitel played the role in Red Dragon (2002).
- He has appeared in four films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Nashville (1975), Apocalypse Now (1979), The Right Stuff (1983) and The Silence of the Lambs (1991).
- His wife, Carol Schwartz Glenn, is a ceramist.
- Shares the role of astronaut Alan Shepard with his The Silence of the Lambs (1991) cast mate Ted Levine.
- Appeared in two movies with Denzel Washington, Courage Under Fire (1996) and Training Day (2001). Both played the role of John Creasy, though Denzel was close to 50 while he played the part and Scott Glenn was in his mid 40s when he starred as John Creasy in Man on Fire in the 80s.
- Was considered for the role of Sam Bowden in Cape Fear (1991).
- Brother of Bonnie Glenn and Terry Glenn.
- Appears in Puerto Vallarta Squeeze (2004) opposite Harvey Keitel, with whom he shares the role of Jack Crawford in the Hannibal Lecter series.
- Has a small part in Apocalypse Now (1979). The lead role was originally given to Harvey Keitel, who went on to succeed Glenn in the role of Jack Crawford in the The Silence of the Lambs (1991) prequel, Red Dragon (2002).
- His The Silence of the Lambs (1991) character, Jack Crawford, was written out of the adaptation of the sequel, Hannibal (2001). Nevertheless, later that year he appeared in The Shipping News (2001) with Julianne Moore.
- Portrayed an ex-CIA agent in Man on Fire (1987). Denzel Washington portrayed an ex-CIA agent on the remake of Man on Fire (2004). Both actors appeared in Training Day (2001).
- Son of Elizabeth and Theodore Glenn.
- Was considered to play either Connor MacLeod or Victor Kurgan in Highlander (1986).
- Was considered for Mr. Joshua in Lethal Weapon (1987).
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