David Hyde Pierce in The Powers That Be (1992)

Kelsey Grammer, David Hyde Pierce, John Mahoney, Peri Gilpin, and Jane Leeves in Frasier (1993)

David Hyde Pierce in Wet Hot American Summer: First Day of Camp (2015)

David Hyde Pierce and Rob Huebel in Wet Hot American Summer: First Day of Camp (2015)

Ron Perlman, David Hyde Pierce, Jeffrey Tambor, and Doug Jones in Hellboy (2004)

Ron Perlman, David Hyde Pierce, and Doug Jones in Hellboy (2004)

David Hyde Pierce and Doug Jones in Hellboy (2004)

David Hyde Pierce, Doug Jones, and Rupert Evans in Hellboy (2004)

Anthony Hopkins and David Hyde Pierce in Nixon (1995)

Meg Ryan, Bill Pullman, David Hyde Pierce, Le Clanché du Rand, Kevin O'Morrison, Tom Tammi, and Valerie Wright in Sleepless in Seattle (1993)

Julianna Margulies and David Hyde Pierce in The Good Wife (2009)

Kelsey Grammer, David Hyde Pierce, John Mahoney, Barbara Babcock, and John Michael Higgins in Frasier (1993)

David Hyde Pierce and Jane Leeves in Frasier (1993)

Kelsey Grammer, David Hyde Pierce, and Jane Leeves in Frasier (1993)

Kelsey Grammer and David Hyde Pierce in Frasier (1993)

Michael J. Fox and David Hyde Pierce in Bright Lights, Big City (1988)

Russell Crowe and David Hyde Pierce in The Exorcism (2024)

David Hyde Pierce, Chloe Bailey, and Ryan Simpkins in The Exorcism (2024)

David Hyde Pierce and Sarah Lancashire in Julia (2022)

David Hyde Pierce, Fran Kranz, and Brittany Bradford in Julia (2022)

David Hyde Pierce and Bebe Neuwirth in Julia (2022)

David Hyde Pierce, Bebe Neuwirth, and Sarah Lancashire in Julia (2022)

David Hyde Pierce and Fiona Glascott in Julia (2022)

Kelsey Grammer, David Hyde Pierce, John Mahoney, Peri Gilpin, Jane Leeves, Dan Butler, and Moose in Frasier (1993)

Kelsey Grammer, David Hyde Pierce, John Mahoney, Peri Gilpin, Jane Leeves, and Moose in Frasier (1993)

David Duchovny, Julia Roberts, David Hyde Pierce, Catherine Keener, Mary McCormack, Blair Underwood, and Nicky Katt in Full Frontal (2002)