- Ended up making more money from his 10% ownership in The Odd Couple (1970) than from the $7000 per episode he received during the show's final season.
- The last surviving juror from the cast of the original 12 Angry Men (1957), Juror number five.
- He enjoyed betting on the horses from the tender age of 15. His own thoroughbred, "Jacklin Klugman", finished third in the 1980 Kentucky Derby.
- His favorite episode of The Odd Couple (1970) was Password (1972).
- Diagnosed with throat cancer in 1974 culminated with vocal surgery in 1989, which left Klugman's voice harsh and gravelly. Both his cancer and scratchy voice were written into several of his later film and television roles, including The Odd Couple: Together Again (1993), Dear God (1996), and Diagnosis Murder (1993).
- Attended Carnegie-Mellon University.
- Was believed to have been involved in a long and bitter feud with actor Norman Fell that lasted over 40 years. However, it was later revealed by Klugman that he and Fell got along fine and the feud was nothing more than a friendly rivalry.
- He and Tony Randall performed together in The Pirate's House (1955), from the "Golden Age of Television," 15 years before they did the classic sitcom, The Odd Couple (1970).
- He reunited with Tony Randall on Broadway in 1998 for Neil Simon's "The Sunshine Boys".
- Won two Emmys for The Odd Couple (1970).
- Was nominated for Broadway's 1960 Tony Award as Best Supporting or Featured Actor (Musical) for "Gypsy".
- Lived with Barbara Neugass from 1978 to 1992. Their relationship ended in 1992. She claimed Jack Klugman promised her lifetime support as his common law wife. One of the reasons her case failed was because Klugman was still married at the time. On 1 December 1999, a Los Angeles jury rejected an $881,000 palimony claim by her.
- Was no stranger to hard times from birth: as a child he had been made to work as a street peddler, and during especially lean stints in his early acting career he would sell his blood for $5 a pint.
- Wed girlfriend Peggy Crosby at The Little Brown Church in Studio City, California (2 February 2008).
- Performed a one-man show "An Evening with Jack Klugman" at the Falcon Theatre in Burbank, California, Sept. 12 - Oct. 19, 2003. (September 2003)
- Was roasted on the The Best of the Dean Martin Celebrity Roasts (1998).
- Competed in Celebrity Challenge of the Sexes (1977) in billiards. He won the match but lost by default because he forgot to call the final shot as per the rules.
- He and Brett Somers legally separated in 1977. Due to religious beliefs, they did not divorce and remained married until her death.
- Appears in the original film, 12 Angry Men (1957), which was remade with Jack Lemmon. Klugman later appeared in the television series, The Odd Couple (1970), which was based on the film The Odd Couple (1968) in which Lemmon co-starred as Felix Unger. In April 2012 he performed "12 Angry Men" at the George Street Playhouse in New Brunswick, NJ, in another role.
- He considered Henry Fonda to be the greatest actor he ever worked with.
- As a film character actor, Klugman was the epitome of the everyman. He was one of the pioneers of television acting in the 1950s and is best remembered for his 1970s television work as Oscar Madison on The Odd Couple (1970) and as the medical examiner on Quincy, M.E. (1976).
- Served on the board of directors of New York's National Actors Theatre.
- He was once part owner of a racehorse named "Jaklin Klugman".
- Uncle of Deborah Klugman and brother of Maurice Klugman.
- Passed away on same day as actor Charles Durning.
- Appeared in James Sweet's "The Value of Names" at the George Street Playhouse in New Brunswick, NJ. (November 2006)
- Jack Klugman's ashes are interred at Westwood Memorial Park in Los Angeles, directly above that of two sisters with the last name of Unger. Klugman's Oscar Madison on TV's "The Odd Couple" played opposite Tony Randall's Felix Unger.
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