Graduated from the University of Washington with a Bachelors of Fine Arts (BFA) degree in 1982.
Has two younger brothers.
Kyle has Scottish, English, Cornish, and German ancestry. He has, perhaps jokingly, stated that he could be a direct descendant of composer Johann Sebastian Bach (1685-1750), through Kyle's maternal great-grandmother, Henrietta Bach. However, Henrietta was descended, through her own patrilineal line, from a man named Johann Christoph Bach, born in Germany in the late 1600s. Thus, Kyle is not a direct descendant of Johann Sebastian Bach nor his other musician relatives (at least through that line).
He turned down the Charlie Sheen role in Platoon (1986).
Often stars in David Lynch films such as Dune (1984), Blue Velvet (1986), Twin Peaks: Fire Walk with Me (1992), and the television series Twin Peaks (1990), originated by Lynch and Mark Frost.
Married Desiree Gruber at Plymouth Congregational Church in Miami, Florida (her hometown).
Director Bruce Beresford said about him: "Kyle wears his handsomeness easily; he doesn't carry on. And he's not a boring man. He's ordinary but interesting, which is difficult to find."
Graduated from Eisenhower High School in Yakima, Yakima County, Washington, in 1977.
Kyle and his wife, Desiree Gruber, became the parents of their first child, a son named Callum Lyon MacLachlan, on July 25, 2008. Callum weighed in at 8 lbs. 6 oz.
Brother of Craig MacLachlan and Kent MacLachlan.
Spells his last name differently than his father Kent McLachlan, who died in 2011 at age 77.
In Sydney, Australia, filming Mao's Last Dancer (2009). [May 2008]
The name of his winery, "Pursued by Bear," was suggested one evening over dinner by Fred Savage, referring to a stage direction in a Shakespeare play. As the story goes, Shakespeare only ever wrote one stage direction in any of his plays (that job was generally left for stage managers), as included in "The Winter's Tale": "Exit, pursued by bear".
Owns a vineyard and winery in the Columbia Valley of Washington State with business partner Eric Dunham. Other than his well known love of wine, his main reason for purchasing a vineyard was to spend more time with his father, Kent McLachlan, who had recently retired from being an attorney and stock broker.
He maintains a website for his family's two dogs (a Jack Russell terrier and a Yorkie/Chihuahua mixed breed), mookieandsam.com, who also have their own YouTube series.
Living with his wife Desiree, and son Callum, in Manhattan, New York City, NY and Columbia Valley, Washington State. 
In one of his roles, as the fictional Mayor of Portland, Oregon, on the Independent Film Channel series Portlandia (2011), he co-stars with Sarah McLachlan, who spells her last name the same as his father, Kent McLachlan, but is no relation.
When his son, Callum, was born in 2008, he created a new wine vintage at his winery called "Baby Bear".
Was nominated for a 1990 Grammy Award in the category of Best Spoken Word or Non-Musical Recording for the album "Diane...'The Twin Peaks Tapes Of Agent Cooper'".
Of Clan Maclachlan.
Lobbied hard for the role of Batman/Bruce Wayne in Batman (1989) when David Lynch was considered to direct but ultimately Tim Burton wound up in the director's chair & Michael Keaton was eventually cast.
Is a practitioner of Shotokan, Kyokushin, Tae Kwon Do, Hapkido, Judo, & Kickboxing.