Parents are Sam and Helen Reiser.
Began his career as a stand-up comedian.
Attended and graduated from Stuyvesant High School in New York City (1973).
Received his Bachelor's degree from Binghamton University, where he majored in music (piano and composition).
Paul and his Mad About You (1992) co-star, Helen Hunt, were each given $1,000,000 per episode for the 1999 season.
Named his production company, Nuance Productions, after a speech his character gives in the comedy movie Diner (1982).
During his university years, Paul was active in student theater productions at the Hinman Little Theater, an on-campus community theater organization located in Hinman College, his dorm community. This was later renamed the Hinman Production Company.
Best-known by the public for his role as Carter Burke in James Cameron's science-fiction epic Aliens (1986), as well as his starring roles as Michael Taylor in My Two Dads (1987) and as Paul Buchman in Mad About You (1992).
Recently reunited with Helen Hunt for a Mad About You (1992) reunion. [January 2005]
Has two sons: Ezra Samuel Reiser (born 1995) and Leon Reiser (born 2000).
Currently resides with his family in Los Angeles, California.
Is of Romanian Jewish ancestry.