Brother of Dwayne Wayans, Keenen Ivory Wayans, Kim Wayans, Nadia Wayans, Marlon Wayans and Shawn Wayans. Cousin of Craig Wayans. Also has three additional sisters: Elvira, Diedre and Vonnie Wayans.
Father of Damon Wayans Jr. (born 1982), Michael Wayans (born 1985), Cara Mia Wayans (born 1987), and Kyla Wayans (born 1991). Uncle of Damien Dante Wayans.
Along with co-stars Jeff Goldblum and Jim Carrey, his voice was dubbed in certain scenes for Earth Girls Are Easy (1988).
While filming Earth Girls Are Easy (1988), this took approximately 2-1/2 hours for him and co-stars Jeff Goldblum and Jim Carrey to be suited up as the aliens.
Michael Kyle, his character on My Wife and Kids (2001), was ranked #27 in TV Guide's list of the "50 Greatest TV Dads of All Time" [20 June 2004 issue].
Is the author of "Bootleg", a humorous compilation of his own observations with regards to family, children, marriage and politics. The book quickly reached the New York Times Bestseller List (1999).
Attended and graduated from Murry Bergtraum High School in Manhattan, New York City.
Has seven grandchildren. Granddaughter, Ava Marie Jean, was born February 13, 2014.
Friends with Michael Jordan and Jim Carrey.
Was diagnosed with Type 2 diabetes in early 2013.
Only wayans brother to not be involved in the scarey movie series.