Graduated from SUNY Purchase whose alumni are known collectively as "The Purchase Mafia".
Is the daughter of art director Frank Falco and actress Judith Anderson (Judith M. Anderson).
Edie graduated from the acting program at the State University of New York at Purchase. After graduation, she worked as a clown and other similar roles at weddings and birthday parties.
Her father, Frank Falco, was of Italian descent, and her mother, Judith Anderson, had Swedish, English, and Cornish ancestry.
She is one of the few actresses to ever sweep the top three television awards. In 2000, she received the Emmy Award for Outstanding Lead Actress in a Drama Series, The Golden Globe Award for Best Performance by an Actress in a Drama Series, and the SAG Award for Outstanding Performance by a Female Actor in a Drama Series, all in the same year for her performance as "Carmela Soprano" in the HBO series The Sopranos (1999).
Her uncle is renowned fiction writer Ed Falco, who teaches at Virginia Polytechnic Institute and State University.
Has a dog named Marley.
Was diagnosed with breast cancer in February 2004. She recovered the same year.
Has had problems with alcohol and decided to become sober after "one particular night of debauchery". She is an advocate of Alcoholics Anonymous.
One of her earlier roles was in "The King's Creampuffs" at the age of 6.
Adopted a baby boy, and named him Anderson after her mother. It is her mother's maiden name. [December 2004]
Was forced to vacate the role of "Jenny" in Broadway's "The Threepenny Opera" due to her commitments to The Sopranos (1999). She was replaced by Cyndi Lauper.
Adopted a baby girl from Florida and named her Macy (February 2008).
Was in a relationship with Stanley Tucci from April 2003 until March 2004. They met while working together on "Frankie and Johnny in the Claire De Lune" on Broadway.
Won $250,000 for Project ALS on a 2001 celebrity episode of "Who Wants to Be a Millionaire?".
Nominated for a 2011 Tony Award as Best Performance by a Featured Actress in a Play for "The House of Blue Leaves".
In 2013, she teamed up with PETA in an ad urging parents to keep their children away from the circus.
Was once mistaken for actress Felicity Huffman at Disneyworld (FL).
Edie Falco's twenty-second (22) Screen Actors Guild 2016 nomination for "Female Actor in a Comedy Series" - Showtimes' "Nurse Jackie" - makes Edie Falco the most nominated performer/actor in SAG Awards history.
Nominated for the 2018 Emmy Award in the Lead Actress in a Limited Series or Movie category for her role as Leslie Abramson in Law & Order True Crime (2017), but lost to Regina King from Seven Seconds (2018).