- Earned a B.A. in Economics from Columbia University in 1978.
- Son of director Melvin Van Peebles and German actress Maria Marx. Father of Maya Van Peebles, Marley Van Peebles, Mandela Van Peebles. Brother of Megan Van Peebles Max Van Peebles, Marguerite Van Peebles, and Makaylo Van Peebles.
- Mother is German actress Maria Marx.
- Mario appeared in the music video of Billy Joel's song "A Matter of Trust" in 1986.
- His movie debut came when he was 12 in his father's 1971 film Sweet Sweetback's Baadasssss Song (1971), where he had a love scene with an older woman.
- Has his own movie production company named "MVP Filmz".
- Was considered for the role of Detective Odafin 'Fin' Tutuola on Law & Order: Special Victims Unit (1999).
- Chosen by People magazine as one of the 50 Most Beautiful People in the world. (1991)
- He is also the father of Morgana Van Peebles, with mother, Chittra Suku.
- Uncle of Ronald Van Jr. and Roman Van.
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